大分割适形调强放射治疗对非小细胞肺癌患者的治疗效果  

The Therapeutic Effect of Hypofractionated Conformal Intensity Modulated Radiotherapy on Non-small Cell Lung Cancer Patients

作　　者：温江妹 郑庆伟[1] Wen Jiangmei;Zheng Qingwei(The Second Hospital of Longyan City,Fujian Province,Longyan Fujian 364000,China)

机构地区：[1]福建省龙岩市第二医院,福建龙岩364000

出　　处：《医疗装备》2024年第2期15-17,21,共4页Medical Equipment

摘　　要：目的探讨大分割适形调强放射治疗用于非小细胞肺癌(NSCLC)患者的疗效观察。方法选取2021年10月至2022年10月医院收治的86例NSCLC患者作为研究对象,按照随机数字表法分为对照组和试验组,每组43例。对照组实施常规分割适形调强放射治疗,试验组实施大分割适形调强放射治疗。比较两组的治疗总有效率、肿瘤标志物[糖类抗原125(CA125)、癌胚抗原(CEA)]水平、免疫功能指标(CD3^(+)、CD4^(+)、CD8^(+))水平及并发症(恶心呕吐、骨髓抑制、贫血、放射性肺炎)发生率。结果试验组治疗总有效率高于对照组,差异有统计学意义(P<0.05)。治疗前,两组CA125、CEA、CD3^(+)、CD4^(+)、CD8^(+)水平比较,差异均无统计学意义(P>0.05);治疗后,两组CA125、CEA、CD3^(+)、CD4^(+)水平均低于同组治疗前,CD8^(+)水平高于同组治疗前,且试验组CA125、CEA、CD3^(+)、CD4^(+)水平均低于对照组,CD8^(+)水平高于对照组,差异均有统计学意义(P<0.05)。两组并发症发生率比较,差异无统计学意义(P>0.05)。结论大分割适形调强放射治疗对NSCLC患者的治疗效果优于常规分割适形调强放射治疗,可降低肿瘤标志物水平,改善机体免疫功能,且不增加并发症发生风险。Objective The therapeutic effect of hypofractionated conformal intensity modulated radiotherapy on non-small cell lung cancer(NSCLC)patients was explored.Methods With the selection of 86 NSCLC patients admitted to the hospital from October 2021 to October 2022 as the study subjects,they were randomly divided into the control group and the experimental group used a random number table method,with 43 patients in each group.With the control group received conventional fractionated conformal intensity modulated radiation therapy,and the experimental group received hypofractionated conformal intensity modulated radiotherapy,the total effective rate of treatment,levels of tumor markers[carbohydrate antigen 125(CA125),carcinoembryonic antigen(CEA)],levels of immune function indicators(CD3^(+),CD4^(+),CD8^(+)),and incidence of complications(nausea and vomiting,bone marrow suppression,anemia,radiation pneumonia)were compared between the two groups.Results The total effective rate of treatment in the experimental group was higher than that in the control group,and the difference was statistically significant(P<0.05).Before treatment,there were no statistically significant differences in the levels of CA125,CEA,CD3^(+),CD4^(+),and CD8^(+)between the two groups(P>0.05);After treatment,the levels of CA125,CEA,CD3^(+),and CD4^(+)in both groups were lower than before treatment in the same group,while the levels of CD8^(+)were higher than before treatment in the same group.Moreover,the levels of CA125,CEA,CD3^(+),and CD4^(+)in the experimental group were lower than those in the control group,and the levels of CD8^(+)were higher than those in the control group,with statistical significance(P<0.05).There was no statistically significant difference in the incidence of complications between the two groups(P>0.05).Conclusion The therapeutic effect of hypofractionated conformal intensity modulated radiotherapy on NSCLC patients is better than that of conventional fractionated conformal intensity modulated radiation therapy,which can r

关 键 词：大分割适形调强放射治疗 非小细胞肺癌 肿瘤标志物 免疫功能 

分 类 号：R730.55[医药卫生—肿瘤]