口腔硬组织修复材料仿生设计制备和临床转化  

Bionic design,preparation and clinical translation of oral hard tissue restorative materials

作　　者：赵菡 卫彦[2] 张学慧[3] 杨小平 蔡晴 宁成云[5] 徐明明[2] 刘雯雯 黄颖[2] 何颖 郭亚茹 江圣杰 白云洋[2] 吴宇佳[2] 郭雨思 郑晓娜 李文静 邓旭亮[2] ZHAO Han;WEI Yan;ZHANG Xuehui;YANG Xiaoping;CAI Qing;NING Chengyun;XU Mingming;LIU Wenwen;HUANG Ying;HE Ying;GUO Yaru;JIANG Shengjie;BAI Yunyang;WU Yujia;GUO Yusi;ZHENG Xiaona;LI Wenjing;DENG Xuliang(Department of General Dentistry,Peking University School and Hospital of Stomatology&National Center for Stomatology&National Clinical Research Center for Oral Diseases&National Engineering Research Center of Oral Biomaterials and Digital Medical Devices&NMPA Key Laboratory for Dental Materials,Beijing 100081,China;Department of Geriatric Dentistry,Peking University School and Hospital of Stomatology&National Center for Stomatology&National Clinical Research Center for Oral Diseases&National Engineering Research Center of Oral Biomaterials and Digital Medical Devices&NMPA Key Laboratory for Dental Materials,Beijing 100081,China;Department of Dental Materials,Peking University School and Hospital of Stomatology&National Center for Stomatology&National Clinical Research Center for Oral Diseases&National Engineering Research Center of Oral Biomaterials and Digital Medical Devices&NMPA Key Laboratory for Dental Materials,Beijing 100081,China;College of Materials Science and Engineering,State Key Laboratory of Organic-Inorganic Composites,Beijing Laboratory of Biomedical Materials,Beijing University of Chemical Technology,Beijing 100029,China;School of Materials Science and Engineering,National Engineering Research Center for Tissue Restoration and Reconstruction,Guangdong Key Laboratory of Biomedical Sciences and Engineering,South China University of Technology,Guangzhou 510006,China)

机构地区：[1]北京大学口腔医学院·口腔医院综合科,国家口腔医学中心,国家口腔疾病临床医学研究中心,口腔生物材料和数字诊疗装备国家工程研究中心,国家药品监督管理局口腔材料重点实验室,北京100081 [2]北京大学口腔医学院·口腔医院特诊科,国家口腔医学中心,国家口腔疾病临床医学研究中心,口腔生物材料和数字诊疗装备国家工程研究中心,国家药品监督管理局口腔材料重点实验室,北京100081 [3]北京大学口腔医学院·口腔医院材料研究室,国家口腔医学中心,国家口腔疾病临床医学研究中心,口腔生物材料和数字诊疗装备国家工程研究中心,国家药品监督管理局口腔材料重点实验室,北京100081 [4]北京化工大学材料科学与工程学院生物材料系,有机无机复合材料国家重点实验室,生物医用材料北京实验室,北京100029 [5]华南理工大学材料科学与工程学院生物材料系,国家人体组织功能重建工程技术研究中心,广东省生物医学工程重点实验室,广州510641

出　　处：《北京大学学报（医学版）》2024年第1期4-8,共5页Journal of Peking University:Health Sciences

基　　金：国家自然科学基金创新研究群体科学基金(82221003);国家自然科学基金重大项目(81991505);国家重点研发计划(2018YFC1105300);国家杰出青年科学基金(81425007,82225012);国家高技术研究发展计划(863计划)(2011AA030102)。

摘　　要：口腔疾病几乎涉及到每个个体,严重影响人民健康和生活质量,已经成为制约国民经济发展和社会资源积累的重要问题。牙齿和颌骨是行使口腔功能和支撑外貌轮廓的重要结构基础。小范围牙齿缺损可能引发牙本质过敏症,大范围缺损则会导致牙齿形态和功能破坏,而牙齿缺失常造成牙槽骨吸收低平,不利于后续修复。临床上牙本质过敏症治疗手段非常有限,以牙本质小管封闭为主,其效果不佳且易复发;材料充填是牙体缺损治疗的主要手段,但现有材料与牙齿力学性能匹配差,界面结合不足,修复体寿命短;而牙槽骨低平的垂直骨增量则是世界性难题。究其原因,是缺乏对牙齿微观结构及其构效关系的深入解析,缺少对牙槽骨再生微环境的深入认识,导致材料设计忽视了从微观结构功能仿生到宏观效果实现的协同考量。因此,发展牙齿/颌骨结构与功能高度仿生的修复材料新技术与临床新策略是目前口腔医学研究的重要战略方向。SUMMARY Oral diseases concern almost every individual and are a serious health risk to the population.The restorative treatment of tooth and jaw defects is an important means to achieve oral function and support the appearance of the contour.Based on the principle of“learning from the nature”,Deng Xuliang’s group of Peking University School and Hospital of Stomatology has proposed a new concept of“microstructural biomimetic design and tissue adaptation of tooth/jaw materials”to address the worldwide problems of difficulty in treating dentine hypersensitivity,poor prognosis of restoration of tooth defects,and vertical bone augmentation of alveolar bone after tooth loss.The group has broken through the bottleneck of multi-stage biomimetic technology from the design of microscopic features to the enhancement of macroscopic effects,and invented key technologies such as crystalline/amorphous multi-level assembly,ion-transportation blocking,and multi-physical properties of the micro-environment reconstruction,etc.The group also pioneered the cationic-hydrogel desensitizer,digital stump and core integrated restorations,and developed new crown and bridge restorative materials,gradient functionalisation guided tissue regeneration membrane,and electrically responsive alveolar bone augmentation restorative membranes,etc.These products have established new clinical strategies for tooth/jaw defect repair and achieved innovative results.In conclusion,the research results of our group have strongly supported the theoretical improvement of stomatology,developed the technical system of oral hard tissue restoration,innovated the clinical treatment strategy,and led the progress of the stomatology industry.

关 键 词：牙齿修复材料 骨组织引导再生膜 电学微环境 骨充填材料 生物力学 

分 类 号：R781.05[医药卫生—口腔医学]