临床少见前列腺癌研究进展  

Clinically rare subtypes of prostate cancer:Progress in research

作　　者：盛正成 董杰 许松 SHENG Zheng-cheng;DONG Jie;XU Song(Department of Urology,General Hospital of Eastern Theater Command,Nanjing,Jiangsu 210002,China)

机构地区：[1]东部战区总医院泌尿外科,江苏南京210002

出　　处：《中华男科学杂志》2023年第3期264-268,共5页National Journal of Andrology

基　　金：国家重点研发计划项目(2018YFC1004303)。

摘　　要：前列腺癌目前已经成为男性最常见的泌尿系肿瘤。临床工作中我们会遇到少部分特殊类型的前列腺癌亚型患者,这些患者疾病进展快,容易出现复发、转移,单一内分泌治疗疗效欠佳,总体生存期较常见的前列腺腺癌患者短。新型靶向药物、基因检测等手段对患者进行早期诊断、早期治疗或许能够进一步延长患者的生存期。本文对临床少见的三种前列腺癌亚型的流行病学特点、起源、分子调控机制、临床特点及治疗分别进行总结和展望。Prostate cancer has now become the most common urinary tract tumor in men.Some special subtypes of prostate cancer are occasionally found clinically,which are characterized by rapid disease progression,easy recurrence and metastasis,poor effect of single endocrine therapy,and shorter overall survival of the patients than those with common prostate adenocarcinoma.Early diagnosis and early treatment with novel targeting drugs and genetic tests may prolong the survival of the patients.This review presents an overview and a prospect of the epidemiological features,origin,molecular regulation mechanisms,clinical characteristics and treatment of three rare subtypes of prostate cancer.

关 键 词：前列腺腺癌 神经内分泌前列腺癌 前列腺导管内癌 前列腺导管腺癌 靶向治疗 

分 类 号：R737.25[医药卫生—肿瘤]