食管癌组织中E钙粘素、原黏蛋白α3的表达水平及临床意义  

The Expression Level and Clinical Significance of E-cadherin and Protomucinα3 in Esophageal Cancer Tissue

作　　者：刘文文 祖萌萌 薛会元 候晓丽 LIU Wenwen;ZU Mengmeng;XUE Huiyuan(Henan University of Traditional Chinese Medicine Fifth Clinical Medical College(Zhengzhou People's Hospital),Zhengzhou,450000)

机构地区：[1]河南中医药大学第五临床医学院,郑州人民医院,450000

出　　处：《实用癌症杂志》2024年第2期197-199,共3页The Practical Journal of Cancer

摘　　要：目的分析E钙粘素、原黏蛋白α3(PCDHA3)在食管癌组织内的表达及意义。方法选取90例食管癌患者,术中取其癌组织与癌旁正常组织,以免疫组织化学法检测PCDHA3表达。另收集患者年龄、性别等资料,探究PCDHA3表达与患者各项临床病理特征间的联系。结果癌组织中E钙粘素阳性表达率为12.22%(11/90)、PCDHA3阳性表达率为17.78%(16/90),低于癌旁组织中的64.44%(58/90)、47.78%(43/60),有统计学差异(P<0.05)。E钙粘素、PCDHA3表达与患者的TNM分期、分化程度、淋巴结转移有关(P<0.05)。结论E钙粘素、PCDHA3在食管癌组织内呈异常低表达,两者参与疾病的发生与发展。Objective To analyze E-cadherin and protomucinαThe expression and significance of PCDHA3 in esophageal cancer tissue.Methods 90 patients with esophageal cancer were selected,and their cancer tissue and normal adjacent tissues were taken during surgery.The expression of PCDHA3 was detected using immunohistochemistry.Collect patient age,gender,and other data to explore the relationship between PCDHA3 expression and various clinical and pathological characteristics of patients.Results The positive expression rate of E-cadherin in cancer tissue was 12.22%(11/90),and the positive expression rate of PCDHA3 was 17.78%(16/90),which was lower than 64.44%(58/90)and 47.78%(43/60)in adjacent tissues,with statistical differences(P<0.05).The expression of E-cadherin and PCDHA3 is related to TNM staging,differentiation,and lymph node metastasis in patients(P<0.05).Conclusion E-cadherin and PCDHA3 exhibit abnormally low expression in esophageal cancer tissue,and both are involved in the occurrence and development of the disease.

关 键 词：食管癌 E钙粘素 原黏蛋白α3 淋巴结转移 

分 类 号：R735.1[医药卫生—肿瘤]