OGDHL、FHL1在非小细胞肺癌组织中的表达及其临床意义  

Expression of OGDHL and FHL1 in Non-small Cell Lung Cancer and Its Clinical Significance

作　　者：张春晓[1] 张群妹[1] 鲁广建[1] ZHANG Chunxiao;ZHANG Qunmei;LU Guangjian(The First Affiliated Hospital of Xinxiang Medical College,Xinxiang,453100)

机构地区：[1]新乡医学院第一附属医院,453100

出　　处：《实用癌症杂志》2024年第2期200-204,共5页The Practical Journal of Cancer

摘　　要：目的分析OGDHL、4个半LIM结构域蛋白1(FHL1)在非小细胞肺癌组织中的表达水平及其临床意义。方法选取80例非小细胞肺癌患者癌组织标本、癌旁组织标本(距肿瘤边缘4cm处),采用免疫组织化学染色法检测所有标本组织中OGDHL、FHL1表达水平。采用χ^(2)检验分析OGDHL、FHL1表达与患者病理特征的关系,采用Kaplan-Meier生存曲线分析OGDHL、FHL1表达与患者预后的关系,多因素Cox回归模型分析非小细胞肺癌患者预后的影响因素。结果非小细胞肺癌患者癌组织OGDHL高表达率明显低于癌旁组织(35.00%vs 62.50%,P<0.05),FHL1高表达率明显高于癌旁组织(67.50%vs 40.00%,P<0.05)。OGDHL、FHL1表达水平与非小细胞肺癌患者TNM分期、淋巴结转移、分化程度密切相关(P<0.05)。OGDHL高表达患者术后5年总生存率为82.14%,低表达患者术后5年总生存率为36.54%,两者比较差异有统计学意义(P<0.05);FHL1高表达患者术后5年总生存率为40.74%,低表达患者术后5年总生存率为76.92%,两者比较差异有统计学意义(P<0.05)。单因素分析得出,TNM分期、淋巴结转移、分化程度、OGDHL表达、FHL1表达均与非小细胞肺癌患者预后密切相关(P<0.05)。TNMⅢ期、淋巴结转移、低分化、OGDHL低表达、FHL1高表达均为影响非小细胞肺癌患者预后的独立危险因素(P<0.05)。结论非小细胞肺癌患者癌组织中OGDHL蛋白呈低表达,FHL1蛋白呈高表达,两者表达水平与非小细胞肺癌患者的临床病理特征及预后密切相关,能够作为评估患者预后的有效指标。Objective To explore the expression levels and clinical significance of OGDHL and four half-LIM domain protein 1(FHL1)in non-small cell lung cancer tissues.Methods The cancer tissue specimens and paracancerous tissue specimens(4 cm from the tumor edge)of 80 cases with non-small cell lung cancer were selected,and then immunohistochemical staining was used to detect the expression levels of OGDHL and FHL1 in all specimens.Theχ^(2)test was used to analyze the relationship between the expression of OGDHL,FHL1 and the pathological characteristics of cases with non-small cell lung cancer,and the Kaplan-Meier survival curve was used to analyze the relationship between the expression of OGDHL and FHL1 and the prognosis of cases,and multivariate Cox regression model was used to analyze the influence factors of the prognosis of cases with non-small cell lung cancer.Results The high expression rate of OGDHL in cancer tissue of cases with non-small cell lung cancer was lower than that in adjacent tissue(35.00%vs 62.50%,P<0.05),and the high expression rate of FHL1 was higher than that in adjacent tissue(67.50%vs 40.00%,P<0.05).The expression levels of OGDHL and FHL1 were closely related to the TNM stage,lymph node metastasis and differentiation degree of cases with non-small cell lung cancer(P<0.05).The 5-year overall survival rate of cases with high OGDHL expression after operation was 82.14%,and the 5-year overall survival rate of cases with low expression of OGDHL after operation was 36.54%(P<0.05).The 5-year overall survival rate of cases with high OGDHL expression was 40.74%,and the 5-year overall survival rate of the patients with low expression after operation was 76.92%(P<0.05).TNM stage,lymph node metastasis,degree of differentiation,OGDHL expression and FHL1 expression were closely related to the prognosis of patients with non-small cell lung(P<0.05).TNM stageⅢ,lymph node metastasis,poor differentiation,low expression of OGDHL and high expression of FHL1 were independent risk factors for the prognosis of cases wi

关 键 词：非小细胞肺癌 OGDHL 4个半LIM结构域蛋白1 预后 

分 类 号：R734.2[医药卫生—肿瘤]