LncRNA MIAT、LASP1蛋白在甲状腺癌组织中的表达及与预后的相关性  

The Expression of LncRNA MIAT and LASP1 Proteins in Thyroid Cancer Tissue and Their Correlation with Prognosis

作　　者：何倩影 刘洋[1] 李红强[1] HE Qianying;LIU Yang;LI Hongqiang(Thyroid Surgery Department of the First Affiliated Hospital of Zhengzhou University,Zhengzhou,450000)

机构地区：[1]郑州大学第一附属医院,450000

出　　处：《实用癌症杂志》2024年第2期216-218,232,共4页The Practical Journal of Cancer

摘　　要：目的探讨长链非编码RNA心肌梗死相关转录本(LncRNA MIAT)、LIM和SH3蛋白1(LASP1)蛋白在甲状腺癌组织内的表达水平及与预后的关系。方法选取63例甲状腺癌患者,收集其癌组织、癌旁正常组织,测定LncRNA MIAT、LASP1蛋白表达水平,并进行对比分析;同时分析LncRNA MIAT、LASP1蛋白表达与甲状腺癌患者临床病理特征的关系;另随访3年,分析LncRNA MIAT、LASP1蛋白表达与甲状腺癌患者预后的关系。结果癌组织LncRNA MIAT相对表达量与LASP1蛋白阳性表达率均高于癌旁正常组织,有统计学差异(P<0.05)。LncRNA MIAT、LASP1蛋白表达与甲状腺癌患者的淋巴结转移、临床分期有关,有统计学差异(P<0.05);LncRNA MIAT高表达、LASP1蛋白阳性表达患者的3年生存率低于LncRNA MIAT低表达、LASP1蛋白阴性表达患者,有统计学差异(P<0.05)。结论LncRNA MIAT、LASP1蛋白在甲状腺癌组织中表现为高水平,其表达水平与患者临床分期、淋巴结转移有关,且表达水平越高,患者预后越差。Objective To investigate the expression levels of long chain non coding RNA myocardial infarction associated transcripts(LncRNA MIAT),LIM,and SH3 protein 1(LASP1)proteins in thyroid cancer tissue and their relationship with prognosis.Methods 63 patients with thyroid cancer were selected,and their cancer tissue and adjacent normal tissue were collected.The expression levels of LncRNA MIAT and LASP1 proteins were measured and compared for analysis;Simultaneously analyzing the relationship between the expression of LncRNA MIAT and LASP1 proteins and the clinical pathological characteristics of thyroid cancer patients;Follow up for another 3 years to analyze the relationship between the expression of LncRNA MIAT and LASP1 proteins and the prognosis of thyroid cancer patients.Results The relative expression level of LncRNA MIAT and the positive expression rate of LASP1 protein in cancer tissue were higher than those in normal tissues adjacent to cancer,with a statistical difference(P<0.05).The expression of LncRNA MIAT and LASP1 proteins is correlated with lymph node metastasis and clinical staging in thyroid cancer patients,with statistical differences(P<0.05);The 3-year survival rate of patients with high expression of LncRNA MIAT and positive expression of LASP1 protein was lower than that of patients with low expression of LncRNA MIAT and negative expression of LASP1 protein,with statistical differences(P<0.05).Conclusion LncoRNA MIAT and LASP1 proteins exhibit high levels in thyroid cancer tissue,and their expression levels are related to clinical stage and lymph node metastasis of patients.The higher the expression level,the worse the prognosis of patients.

关 键 词：甲状腺癌 长链非编码RNA心肌梗死相关转录本 LIM和SH3蛋白1 预后 生存率 临床分期 

分 类 号：R736.1[医药卫生—肿瘤]