miR-92a、sICAM-1、VEGF在乳腺癌组织中的表达及其与超声血流参数的相关性研究  

Study on the Expression of miR-92a、sICAM-1 and VEGF in Breast Cancer and Its Correlation with Ultrasonic Blood Flow Parameters

作　　者：常正江 陈小龙[1] CHANG Zhengjiang;CHEN Xiaolong(Yan'an People's Hospital,Yan'an,716000)

机构地区：[1]陕西省延安市人民医院,716000

出　　处：《实用癌症杂志》2024年第2期300-303,共4页The Practical Journal of Cancer

摘　　要：目的探讨微小核糖核酸-92a(miR-92a)、可溶性细胞间黏附分子-1(sICAM-1)、血管内皮生长因子(VEGF)在乳腺癌组织中的表达差异,并分析其与患者超声血流参数的相关性。方法选取乳腺癌患者102例作为乳腺癌组,同期收集乳腺良性肿瘤患者100例作为对照组。比较miR-92a、sICAM-1、VEGF在两组间的表达,分析其诊断价值。采用多普勒超声检测患者病变部位的血流参数,主要包括动脉血流峰值速度(PSV)、舒张末期血流速度(EDV)、脉动指数(PI)、阻力指数(RI),分析miR-92a、sICAM-1、VEGF与乳腺超声血流参数的相关性。结果乳腺癌组患者miR-92a、sICAM-1、VEGF水平明显高于对照组,差异具有统计学意义(P<0.05),三项联合检测诊断乳腺癌的曲线下面积(AUC)为0.897,灵敏度为89.3%,特异度为90.0%。Logistic回归分析显示miR-92a、sICAM-1、VEGF是乳腺癌发生的重要危险因素(P<0.05)。乳腺癌组患者的PSV、EDV明显高于对照组,PI、RI明显低于对照组,差异具有统计学意义(P<0.05)。Spearman相关性分析结果显示miR-92a、sICAM-1、VEGF水平与PSV、EDV呈正相关,与PI、RI呈负相关(P<0.05)。结论miR-92a、sICAM-1、VEGF在乳腺癌患者中明显升高,且与患者超声血流参数密切相关,是乳腺癌发生的重要危险因素,三项联合检测有助于乳腺癌的早期诊断及病情评估。Objective To investigate the expression differences of Micrornas-92a(miR-92a),soluble intercellular adhesion molecule-1(sICAM-1)and vascular endothelial growth factor(VEGF)in patients with breast cancer,and to analyze their correlation with ultrasound blood flow parameters.Methods 102 patients with breast cancer were retrospectively collected as the breast cancer group,and 100 patients with benign breast tumor were collected as the control group.The expressions of miR-92a,sICAM-1 and VEGF in the 2 groups were compared to analyze their diagnostic value.Doppler ultrasound was used to detect blood flow parameters at the lesion site of patients,mainly including peak arterial flow velocity(PSV),end-diastolic flow velocity(EDV),pulsation index(PI)and resistance index(RI),and to analyze the correlation between miR-92a,sICAM-1,VEGF and breast ultrasound blood flow parameters.Results The levels of miR-92a,sICAM-1 and VEGF in the breast cancer group were significantly higher than those in the control group,and the differences were statistically significant(P<0.05).The area under curve(AUC)of the three combined tests for the diagnosis of breast cancer was 0.897,with a sensitivity of 89.3%and specificity of 90.0%.Logistic regression analysis showed that miR-92a,sICAM-1 and VEGF were important risk factors for breast cancer(P<0.05).PSV and EDV in breast cancer group were significantly higher than those in the control group,while PI and RI were significantly lower than those in the control group,with statistical significance(P<0.05).Spearman correlation analysis showed that the levels of miR-92a,sICAM-1 and VEGF were positively correlated with PSV and EDV,but negatively correlated with PI and RI(P<0.05).Conclusion miR-92a,sICAM-1,and VEGF are significantly elevated in breast cancer patients,and are closely related to the ultrasound blood flow parameters of patients,which are important risk factors for breast cancer.The combined detection of the three can contribute to the early diagnosis and disease evaluation of breast cancer

关 键 词：乳腺癌 微小核糖核酸-92a 可溶性细胞间黏附分子-1 血管内皮生长因子 血流 超声 

分 类 号：R737.9[医药卫生—肿瘤]