CD133、HER2、HIF-1α在胃癌组织中的表达及与患者Hp感染、淋巴结转移和预后的关系分析  

Expression of CD133,HER2,and HIF-1αin gastric cancer and their relationship with Helicobacter pylori infection,lymph node metastasis,and prognosis of patients

作　　者：金欢[1] 许晴晴[1] 薛晓婕[1] JIN Huan;XU Qing-qing;XUE Xiao-jie(Department of Pathology,Huangshi Central Hospital/Affiliated Hospital of Hubei Institute of Technology,Huangshi Hubei 435000,China)

机构地区：[1]黄石市中心医院/湖北理工学院附属医院病理科,湖北黄石435000

出　　处：《临床和实验医学杂志》2024年第1期16-20,共5页Journal of Clinical and Experimental Medicine

基　　金：湖北省卫健委基金项目(编号:WJ2019H449)。

摘　　要：目的探究中性粒细胞表面抗原(CD133)、人类表皮生长因子受体2(HER2)、缺氧诱导因子-1α(HIF-1α)在胃癌组织中的表达及与患者幽门螺杆菌(Hp)感染、淋巴结转移和预后的关系。方法回顾性选取2020年1月至2021年1月在黄石市中心医院/湖北理工学院附属医院进行治疗的100例胃癌患者作为研究对象。所有患者中,存在Hp感染75例,未发生Hp感染25例;存在淋巴结转移45例,未发生淋巴结转移55例。随访2年,56例患者发生复发或死亡,纳入预后不良组,其余44例纳入预后良好组。取患者的胃癌组织及癌旁组织,对组织中CD133、HER2、HIF-1α表达情况进行比较,并探究CD133、HER2、HIF-1α表达情况与患者Hp感染、淋巴结转移和预后的关系,并采用受试者工作特征(ROC)曲线分析CD133、HER2、HIF-1α表达对预后不良的预测价值。结果胃癌组织中CD133、HER2、HIF-1α表达阳性率分别为81.00%、25.00%、66.00%,均高于癌旁组织(18.00%、4.00%、44.00%),差异均有统计学意义(P<0.05)。发生Hp感染的患者中胃癌组织的CD133、HER2、HIF-1α表达阳性率分别为74.67%、30.67%、72.00%,均显著高于未发生Hp感染患者(48.00%、8.00%、48.00%),差异均有统计学意义(P<0.05)。淋巴结转移患者胃癌组织的CD133、HER2、HIF-1α表达阳性率分别为93.33%、48.89%、80.00%,均高于未发生淋巴结转移患者(70.91%、5.45%、54.55%),差异均有统计学意义(P<0.05)。预后不良组患者胃癌组织的CD133、HER2、HIF-1α表达阳性率分别为83.93%、37.50%、75.00%,均显著高于预后良好组患者(47.73%、9.09%、54.55%),差异均有统计学意义(P<0.05)。ROC曲线结果显示,CD133、HER2表达阳性率对胃癌预后不良的预测曲线下面积(AUC)值分别为0.781、0.762,HIF-1α表达阳性率对胃癌预后不良的预测AUC值为0.602。结论CD133、HER2、HIF-1α在胃癌组织及发生感染Hp、淋巴结转移患者中存在高表达,且CD133、HER2表达对患者预后有一Objective To investigate the expression of neutrophil surface antigen(CD133),human epidermal growth factor receptor 2(HER2),and hypoxia-inducible factor-1α(HIF-1α)in gastric cancer tissues and their relationship with Helicobacter pylori(Hp)infection,lymph node metastasis,and patient prognosis.Methods A total of 100 gastric cancer patients treated at Huangshi Central Hospital/Affiliated Hospital of Hubei Institute of Technology from January 2020 to January 2021 were retrospectively selected as the study subjects.Among all the patients,75 cases of Hp infection and 25 cases without Hp infection;45 cases with lymph node metastasis and 55 cases without lymph node metastasis.After 2 years of follow-up,56 patients recurred or died and were included in the poor prognosis group,while the remaining 44 patients were included in the good prognosis group.Gastric cancer tissues and adjacent tissues of patients were collected,and the expression levels of CD133,HER2,and HIF-1αwere compared.The relationship between the expression of CD133,HER2,HIF-1α,Hp infection,lymph node metastasis,and patient prognosis were also explored.The predictive value of CD133,HER2,HIF-1αexpression for poor prognosis were analyzed using receiver operating characteristic(ROC)curve.Results The positive expression rates of CD133,HER2,and HIF-1αin gastric cancer tissues were 81.00%,25.00%,66.00%,which were significantly higher than those in adjacent tissues(18.00%,4.00%,44.00%),the differences were statistically significant(P<0.05).The positive expression rates of CD133,HER2,and HIF-1αin the Hp-infected patients were 74.67%,30.67%,72.00%,which were significantly higher than those in the non-infected patients(48.00%,8.00%,48.00%),the differences were statistically significant(P<0.05).The positive expression rates of CD133,HER2,and HIF-1αin the lymph node metastasis patients were 93.33%,48.89%,80.00%,which were higher than those in the non-metastasis patients(70.91%,5.45%,54.55%),the differences were statistically significant(P<0.05).The positive exp

关 键 词：受体 人类表皮生长因子 缺氧诱导因子 Α亚基 中性粒细胞表面抗原 胃癌 幽门螺杆菌 淋巴结转移 

分 类 号：R735.2[医药卫生—肿瘤]