不同Child-Pugh分级肝硬化患者血清TSP-1、球蛋白/胆碱酯酶的表达水平差异及其疾病预后危险因素分析  

Expression levels of serum TSP-1 and globulin/cholinesterase in patients with liver cirrhosis of different Child-Pugh grades and analysis of risk factors for disease prognosis

作　　者：葛爽[1] 魏娟[1] 谷申森 GE Shuang;WEI Juan;GU Shen-sen(Liver Laparoscopic Surgery,The First Affiliated Hospital of Xinjiang Medical University,Urumqi Xinjiang 830000,China)

机构地区：[1]新疆医科大学第一附属医院肝脏腹腔镜外科,新疆乌鲁木齐830000

出　　处：《临床和实验医学杂志》2024年第2期126-130,共5页Journal of Clinical and Experimental Medicine

基　　金：新疆维吾尔自治区自然科学基金资助项目(编号:2021D01C304)。

摘　　要：目的分析不同Child-Pugh分级肝硬化患者血清凝血酶敏感蛋白-1(TSP-1)、球蛋白/胆碱酯酶的表达水平差异及其疾病预后危险因素。方法回顾性选取2020年2月至2023年2月新疆医科大学第一附属医院收治的70例肝硬化患者作为主要研究对象,根据Child-Pugh分级将其分为Child-Pugh A级组(n=20),Child-Pugh B级组(n=34),Child-Pugh C级组(n=16),另选取同期在本院进行体检的50名健康人群作为对照组。采用酶联免疫吸附试验法检测4组及肝硬化不同预后患者的血清TSP-1、球蛋白、胆碱酯酶、球蛋白/胆碱酯酶表达水平;采用双变量Spearman相关性检验血清TSP-1、球蛋白、胆碱酯酶、球蛋白/胆碱酯酶与肝硬化患者Child-Pugh分级和预后的相关性;建立多因素Logistic模型分析影响肝硬化患者预后的独立危险因素,并绘制受试者工作特征(ROC)曲线分析血清TSP-1、球蛋白/胆碱酯酶对肝硬化预后的预测价值。结果与对照组比较,Child-Pugh A级组、Child-Pugh B级组、Child-Pugh C级组患者的血清TSP-1、球蛋白、球蛋白/胆碱酯酶表达水平较高,血清胆碱酯酶表达水平较低;与Child-Pugh A级组患者比较,Child-Pugh B级组、Child-Pugh C级组患者的血清TSP-1、球蛋白、球蛋白/胆碱酯酶表达水平较高,血清胆碱酯酶表达水平较低;与Child-Pugh B级组比较,Child-Pugh C级组患者的血清TSP-1、球蛋白、球蛋白/胆碱酯酶表达水平较高,血清胆碱酯酶表达水平较低,差异均有统计学意义(P<0.05)。与预后良好组比较,预后不良组血清TSP-1、球蛋白、球蛋白/胆碱酯酶表达水平较高,血清胆碱酯酶表达水平较低,差异均有统计学意义(P<0.05)。肝硬化患者血清TSP-1、球蛋白/胆碱酯酶与Child-Pugh分级和预后均呈正相关(P<0.05)。多因素Logistic分析结果显示,Child-Pugh分级、TSP-1、球蛋白/胆碱酯酶均是影响肝硬化患者预后的独立危险因素(P<0.05)。血清TSP-1、球蛋白/胆碱酯�Objective To analyze the expression levels of serum thrombospondin-1(TSP-1)and globulin/cholinesterase in patients with liver cirrhosis of different Child-Pugh grades and their prognostic risk factors.Methods Seventy patients with liver cirrhosis admitted to The First Affiliated Hospital of Xinjiang Medical University from February 2020 to February 2023 were retrospectively selected as the main research objects.According to Child-Pugh classification,they were divided into Child-Pugh class A group(n=20),Child-Pugh class B group(n=34)and Child-Pugh class C group(n=16).In addition,50 healthy people who underwent physical examination in The First Affiliated Hospital of Xinjiang Medical University during the same period were selected as the control group.The expression levels of serum TSP-1 and globulin/cholinesterase in 4 groups and patients with different prognosis of liver cirrhosis were detected by enzyme-linked immunosorbent assay.Bivariate Spearman correlation was used to test the correlation between serum TSP-1,globulin/cholinesterase and Child-Pugh classification and prognosis in patients with liver cirrhosis.The independent risk factors affecting the prognosis of patients with liver cirrhosis was analyzed by establishing multivariate Logistic model,and the predictive value of serum TSP-1 and globulin/cholinesterase on the prognosis of liver cirrhosis was analyzed by plotting receiver operating characteristic(ROC)curve.Results Compared with the control group,the expression levels of serum TSP-1,globulin and globulin/cholinesterase in patients with Child-Pugh class A group,Child-Pugh class B group and Child-Pugh class C group were higher,and the expression level of serum cholinesterase was lower;compared with patients with Child-Pugh class A group,the expression levels of serum TSP-1,globulin and globulin/cholinesterase in patients with Child-Pugh class B group and Child-Pugh class C group were higher,and the expression level of serum cholinesterase was lower;compared with Child-Pugh class B group,the expressio

关 键 词：肝硬化 CHILD-PUGH分级 凝血酶敏感蛋白-1 球蛋白/胆碱酯酶 预后 危险因素 

分 类 号：R575.2[医药卫生—消化系统]