Reprogramming the tumor immune microenvironment via nanomaterial-mediated dynamic therapy  

作　　者：Wangbo Jiao Yao Feng Chen Liang Qiaoyi Lu Haiming Fan Xing-Jie Liang Xiaoli Liu 

机构地区：[1]Key Laboratory of Synthetic and Natural Functional Molecule Chemistry of the Ministry of Education,College of Chemistry and Materials Science,Northwest University,Xi’an 710069,China [2]Laboratory of Controllable Nanopharmaceuticals,Chinese Academy of Sciences(CAS)Center for Excellence in Nanoscience and CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety,National Center for Nanoscience and Technology,Beijing 100190,China [3]Institute of Regenerative and Reconstructive Medicine,Med-X Institute,First Affiliated Hospital of Xi’an Jiaotong University,Xi’an 710049,China

出　　处：《Nano Research》2023年第12期13100-13112,共13页纳米研究（英文版）

基　　金：supported by the National Key Research and Development Program of China(No.2022YFC2408000);the National Natural Science Foundation of China(NSFC)(Nos.82072063,32001005,32101136,and 82202306);Key Research and Development Program of Shaanxi Province(No.2023-YBSF-132);Shaanxi Province Youth Science and Technology New Star(No.2022KJXX-09);Natural Science Foundation of Shaanxi Province(No.2020JQ610);Science Foundation of Nanjing Chia Tai Tianqing project(No.TQ202215).

摘　　要：Our improved knowledge of tumor immunology laid a solid foundation for the clinical use of tumor immunotherapies such as immune checkpoint blockers,and the efficacy of these drugs increased our confidence that immunomodulation was a viable way of treating cancer.The basis of immunotherapy is to break the immune escape of the tumor and resolve the immune suppressive microenvironment of tumors.Nanomaterial-mediated dynamic therapy(NDT)is an emerging immuno-regulatable type for tumor therapy,whose effects are mediated by increased cellular levels of reactive oxygen species(ROS).ROS is a potent trigger of immunogenic cell death,and this process initiates antitumor immunity.Nanomaterials for use in NDT can be engineered to interact with almost all cell types in the tumor microenvironment to remodel this environment.In this review,we systematically examined the effects of NDT on four major cell types in the tumor microenvironment,namely tumor cells,lymphocytes,myeloid cells,and tumor stromal cells.We believe that this review will improve researchers’understanding of the anti-tumor immunity triggered by NDT,and provide ideas and inspiration for how optimally designed NDT schemes can be used to target the cells in the tumor microenvironment.

关 键 词：tumor immunotherapy tumor immune microenvironment NANOMATERIALS reactive oxygen species immune cells 

分 类 号：R73[医药卫生—肿瘤] R383[医药卫生—临床医学]