Clinical and pathological characteristics and expression of related molecules in patients with airway disseminated lung adenocarcinoma  

作　　者：Wei Luan Shuai Liu Kai Zhang Yin-Zai He 

机构地区：[1]Department of Oncology,Inner Mongolia Autonomous Region People's Hospital,Hohhot,Inner Mongolia,China [2]Thoracic Tumor Surgery,Inner Mongolia Autonomous Region People's Hospital,Hohhot,Inner Mongolia,China

出　　处：《Oncology and Translational Medicine》2024年第1期30-34,共5页肿瘤学与转化医学（英文版）

基　　金：Funded by the Health Science and Technology Program of Inner Mongolia Autonomous Region(no.202201061);Supported by the Joint Project of theMillion Science and Technology Initiatives of Inner Mongolia Medical University(no.YKD2020KJBW(LH)057).

摘　　要：Objective:Lung adenocarcinoma exhibits diverse genetic and morphological backgrounds,in addition to considerable differences in clinical pathology and molecular biological characteristics.Among these,the phenomenon of spread through air space(STAS),a distinct mode of lung cancer infiltration,has rarely been reported.Therefore,this study aimed to explore the relationship between STAS tumor cells and the clinical and molecular characteristics of patients with lung adenocarcinoma,as well as their impact on prognosis.Methods:This study included 147 patients who were diagnosed with lung adenocarcinoma at the Inner Mongolia Autonomous Region Cancer Institute between January 2014 and December 2017.Surgical resection specimens were retrospectively analyzed.Using univariate and multivariate Cox analyses,we assessed the association between STAS and the clinicopathological features and molecular characteristics of patients with lung adenocarcinoma.Furthermore,we investigated the effects on patient prognosis.In addition,we developed a column–line plot prediction model and performed internal validation.Results:Patients with positive STAS had a significantly higher proportion of tumors with a diameter≥2 cm,with infiltration around the pleura,blood vessels,and nerves,and a pathological stage>IIB than in STAS-negative patients(P<0.05).Cox multivariate survival analysis revealed that clinical stage,STAS status,tumor size,and visceral pleural invasion were independent prognostic factors influencing the 5-year progression-free survival in patients with lung adenocarcinoma.The predictive values and P values from the Hosmer-Lemeshow test were 0.8 and 0.2,respectively,indicating no statistical difference.Receiver operating characteristic curve analysis demonstrated areas under the curve of 0.884 and 0.872 for the training and validation groups,respectively.The nomogram model exhibited the best fit with a value of 192.09.Conclusions:Clinical stage,pleural invasion,vascular invasion,peripheral nerve invasion,tumor size,and necrosis

关 键 词：Airway dissemination of tumor cells Lung adenocarcinoma Clinicopathological characteristics NOMOGRAM Prognosis prediction model 

分 类 号：R734.2[医药卫生—肿瘤]