双能量CT定量对乳腺癌免疫组化表达评估的价值  

Clinical value of dual-energy CT to evaluate the immunohistochemical expression of breast cancer

作　　者：周宝鹤 陈春妙 华芬芬 程雪[1] 王祖飞[1] ZHOU Baohe;CHEN Chunmiao;HUA Fenfen;CHENG Xue;WANG Zufei*(Lishui Central Hospital,Lishui 323000,China)

机构地区：[1]丽水市中心医院,浙江丽水323000

出　　处：《浙江实用医学》2023年第3期200-203,216,共5页Zhejiang Practical Medicine

基　　金：丽水市科技局公益性技术应用研究项目(2020GYX17)。

摘　　要：目的 研究双能量CT定量评估乳腺癌患者免疫组化表达的临床价值。方法 对2022年1~12月浙江省丽水市中心医院收治的68例乳腺癌患者进行双能量CT扫描。根据患者免疫组化中雌激素受体(ER)、孕激素受体(PR)以及细胞增殖相关核抗原(Ki-67)情况分组,每个分型均分为阴性和阳性。使用分析软件分析CT图像,记录患者病灶的CT值、标准碘浓度(NIC)、keV-CT值曲线斜率(K),比较阳性和阴性患者能谱参数的差异。结果 ER阴性患者NICa、NICv、Ka以及Kv值均高于ER阳性患者,差异有统计学意义(P<0.05);其余能谱参数ER阳性与阴性患者之间对比差异无统计学意义(P>0.05)。PR阳性患者和阴性患者各能谱参数指标比较差异均无统计学意义(P>0.05)。Ki-67阴性患者Ka值低于阳性患者,差异有统计学意义(P<0.05);其余双能量参数Ki-67阳性患者和阴性患者对比差异无统计学意义(P>0.05)。结论 双能量CT定量评估对乳腺癌患者免疫组化表达具有一定的临床诊断价值,可为临床诊断乳腺癌提供参考。Objective To study the clinical value of dual-energy CT to evaluate the immunohistochemical expressions of breast cancer patients.Methods 68 breast cancer patients treated from January 2021 to December 2021 in Zhejiang Lishui Central Hospital were investigated.The dual-energy CT was performed.According to the immunohistochemical results,patients were defined as negative or positive estrogen receptor(ER),progesterone receptor(PR)and Kiel 67 antigen(Ki-67).Through CT imaging,CT value,the normalized CT(NCT),keV-CT curve rate(K)were recorded;the spectral parameters between positive cases and negative cases were compared.Results NICa、NICv、Ka and Kv values in negative ER patients were higher than positive ER patients,with statistically significant difference(P<0.05);the other spectral parameters between negative and positive ER patients showed no statistically significant difference(P>0.05);the spectral parameters between positive and negative PR patients showed no statistically significant difference(P>0.05);Ka values in negative Ki-67 patients were lower than positive Ki-67 patients,with statistically significant difference(P<0.05);the other spectral parameters between positive and negative Ki-67 patients showed no statistically significant difference(P>0.05).Conclusion The dual-energy CT is available to evaluate the immunohistochemical expressions of breast cancer patients,providing basis on the clinical treatment of breast cancer.

关 键 词：乳腺癌 双能量CT 免疫组化 

分 类 号：R737.9[医药卫生—肿瘤] R730.44[医药卫生—临床医学]