内型异莰烷基甲醛缩氨基硫脲类化合物的合成及抑菌活性  

Synthesis and Antifungal Activity of Endo-isocamphanyl-formaldehyole Thiosemicarbazides

作　　者：丁清颖 昌家宇 肖转泉[2] 胡嘉 王宗德[1] 陈尚钘[1] DING Qingying;CHANG Jiayu;XIAO Zhuanquan;HU Jia;WANG Zongde;CHEN Shangxing(College of Forestry,Jiangxi Agricultural University,East China Woody Fragrance and Flavor Engineering Research Center of National Forestry and Grassland Administration,Camphor Engineering Research Center of NFGA/Jiangxi Province,Nanchang 330045,China;College of Chemistry and Chemical Engineering,Jiangxi Normal University,Nanchang 330022,China)

机构地区：[1]江西农业大学林学院、国家林业草原木本香料(华东)工程技术研究中心、国家林业草原/江西省樟树工程技术研究中心,江西南昌330045 [2]江西师范大学化学化工学院,江西南昌330022

出　　处：《林产化学与工业》2024年第1期105-110,共6页Chemistry and Industry of Forest Products

基　　金：国家自然科学基金资助项目(31960295);江西省重大科技研发专项(20203ABC28W016);江西省主要学科学术和技术带头人培养计划领军人才项目(20204BCJ22022)。

摘　　要：以莰烯衍生物内型异莰烷基甲醛与氨基硫脲衍生物进行缩合反应,合成了5种缩氨基硫脲类化合物(3a~3e),并通过IR、MS、~1H NMR和^(13)C NMR等分析方法对其结构进行了表征。采用菌丝生长速率法测试了化合物3a~3e对水稻纹枯病菌等8种植物病原菌的生长抑制作用,结果表明:5种化合物中,内型异莰烷基甲醛缩氨基硫脲(3a)对8种植物病原菌的抑制率最高,在质量浓度为50 mg/L时,3a对油茶炭疽病菌、枇杷炭疽病菌的抑制率分别为91.9%和97.2%,对油茶果生刺盘孢菌和彩绒革盖菌的抑制率均达100%,对水稻纹枯病菌、松枯梢病病原菌和西瓜枯萎病菌的抑制率分别为80.7%、79.8%、79.5%,均优于阳性对照样百菌清。5 endo-isocamphanyl-formaldehyole thiosemicarbazide compounds(3a-3e) were synthesized by condensation reactions of camphene derivatives endo-isocamphanyl-formaldehyole with thiosemicarbazide derivatives.Their structures were characterized by IR,MS,~1H NMR and ~(13)C NMR.The mycelial growth rate method was used to study the inhibition effects of the related compounds on the growth of 8 plant pathogenic fungi including Rhizoctonia solani.The results showed that,among 5 compounds,the inhibition rate of endo-isocamphanyl-formaldehyole thiosemicarbazide(3a) was the highest against 8 plant pathogenic fungi.At the mass concentration of 50 mg/L,the inhibition rates of 3a against Colletotrichum gloeosporioides and Colletotrichum acutatum were 91.9% and 97.2%,respectively.The inhibition rates of 3a against Colletotrichum fructicola and Coriolus versicolor were both 100%.The inhibition rates of 3a against Rhizoctonia solani,Sphaeropsis sapinea and Fusariumoxyporum f.sp.niveum were 80.7%,79.8% and 79.5%,respectively,which were better than that of the positive control sample of Chlorothalonil.

关 键 词：内型异莰烷基甲醛 氨基硫脲 缩合反应 结构分析 抑菌活性 

分 类 号：TQ35[化学工程] O621.3[理学—有机化学]