Inflammatory response in gastrointestinal cancers:Overview of six transmembrane epithelial antigens of the prostate in pathophysiology and clinical implications  

作　　者：Ze-Xuan Fang Wen-Jia Chen Zheng Wu Yan-Yu Hou Yang-Zheng Lan Hua-Tao Wu Jing Liu 

机构地区：[1]The Breast Center,Cancer Hospital of Shantou University Medical College,Shantou 515041,Guangdong Province,China [2]Department of General Surgery,First Affiliated Hospital of Shantou University Medical College,Shantou 515041,Guangdong Province,China

出　　处：《World Journal of Clinical Oncology》2024年第1期9-22,共14页世界临床肿瘤学杂志（英文版）

基　　金：the National Natural Science Foundation of China,No.82273457;the Natural Science Foundation of Guangdong Province,No.2021A1515012180,2023A1515012762 and No.2019A1515010962;Special Grant for Key Area Programs of Guangdong Department of Education,No.2021ZDZX2040;Science and Technology Special Project of Guangdong Province,No.210715216902829.

摘　　要：Chronic inflammation is known to increase the risk of gastrointestinal cancers(GICs),the common solid tumors worldwide.Precancerous lesions,such as chronic atrophic inflammation and ulcers,are related to inflammatory responses in vivo and likely to occur in hyperplasia and tumorigenesis.Unfortunately,due to the lack of effective therapeutic targets,the prognosis of patients with GICs is still unsatisfactory.Interestingly,it is found that six transmembrane epithelial antigens of the prostate(STEAPs),a group of metal reductases,are significantly associated with the progression of malignancies,playing a crucial role in systemic metabolic homeostasis and inflammatory responses.The structure and functions of STEAPs suggest that they are closely related to intracellular oxidative stress,responding to inflammatory reactions.Under the imbalance status of abnormal oxidative stress,STEAP members are involved in cell transformation and the development of GICs by inhibiting or activating inflammatory process.This review focuses on STEAPs in GICs along with exploring their potential molecular regulatory mechanisms,with an aim to provide a theoretical basis for diagnosis and treatment strategies for patients suffering from these types of cancers.

关 键 词：Six transmembrane epithelial antigens of the prostate Gastrointestinal cancer Inflammation 

分 类 号：R735.34[医药卫生—肿瘤]