Prevalence, risk factors, and BRAF mutation of colorectal sessile serrated lesions among Vietnamese patients  

作　　者：Nhu Thi Hanh Vu Huy Minh Le Diem Thi-Ngoc Vo Hoang Anh Vu Nhan Quang Le Dung Dang Quy Ho Duc Trong Quach 

机构地区：[1]Department of Internal Medicine,University of Medicine and Pharmacy at Ho Chi Minh City,Ho Chi Minh 700000,Viet Nam [2]GI Endoscopy Department,University Medical Center at Ho Chi Minh City,Ho Chi Minh 700000,Viet Nam [3]Department of Histology-Embryology and Pathology,University of Medicine and Pharmacy at Ho Chi Minh City,Ho Chi Minh 700000,Viet Nam [4]Center for Molecular Biomedicine,University of Medicine and Pharmacy at Ho Chi Minh City,Ho Chi Minh 700000,Viet Nam [5]Department of Endoscopy,Cho Ray Hospital,Ho Chi Minh 700000,Viet Nam

出　　处：《World Journal of Clinical Oncology》2024年第2期290-301,共12页世界临床肿瘤学杂志（英文版）

摘　　要：BACKGROUND Sessile serrated lesions(SSLs)are considered precancerous colorectal lesions that should be detected and removed to prevent colorectal cancer.Previous studies in Vietnam mainly investigated the adenoma pathway,with limited data on the serrated pathway.AIM To evaluate the prevalence,risk factors,and BRAF mutations of SSLs in the Vietnamese population.METHODS This is a cross-sectional study conducted on patients with lower gastrointestinal symptoms who underwent colonoscopy at a tertiary hospital in Vietnam.SSLs were diagnosed on histopathology according to the 2019 World Health Organi-zation classification.BRAF mutation analysis was performed using the Sanger DNA sequencing method.The multivariate logistic regression model was used to determine SSL-associated factors.RESULTS There were 2489 patients,with a mean age of 52.1±13.1 and a female-to-male ratio of 1:1.1.The prevalence of SSLs was 4.2%[95%confidence interval(CI):3.5-5.1].In the multivariate analysis,factors significantly associated with SSLs were age≥40[odds ratio(OR):3.303;95%CI:1.607-6.790],male sex(OR:2.032;95%CI:1.204-3.429),diabetes mellitus(OR:2.721;95%CI:1.551-4.772),and hypertension(OR:1.650,95%CI:1.045-2.605).The rate of BRAF mutations in SSLs was 35.5%.CONCLUSION The prevalence of SSLs was 4.2%.BRAF mutations were present in one-third of SSLs.Significant risk factors for SSLs included age≥40,male sex,diabetes mellitus,and hypertension.

关 键 词：Colorectal cancer Sessile serrated lesion BRAF mutation Risk factors Diabetes mellitus Hypertension 

分 类 号：R735.34[医药卫生—肿瘤]