Relationship among Parkinson’s disease, constipation, microbes, and microbiological therapy  

作　　者：Xin-Yang Yuan Yu-Sen Chen Zhou Liu 

机构地区：[1]Department of Neurology,Affiliated Hospital of Guangdong Medical University,Zhanjiang 524000,Guangdong Province,China [2]Institute of Neurology,Guangdong Key Laboratory of Age-Related Cardiac and Cerebral Diseases,Zhanjiang 524000,Guangdong Province,China

出　　处：《World Journal of Gastroenterology》2024年第3期225-237,共13页世界胃肠病学杂志（英文版）

摘　　要：This comprehensive review elucidates the complex interplay between gut microbiota and constipation in Parkinson’s disease(PD),a prevalent non-motor symptom contributing significantly to patients’morbidity.A marked alteration in the gut microbiota,predominantly an increase in the abundance of Proteobacteria and Bacteroidetes,is observed in PD-related constipation.Conventional treatments,although safe,have failed to effectively alleviate symptoms,thereby necessitating the development of novel therapeutic strategies.Microbiological interventions such as prebiotics,probiotics,and fecal microbiota transplantation(FMT)hold therapeutic potential.While prebiotics improve bowel movements,probiotics are effective in enhancing stool consistency and alleviating abdominal discomfort.FMT shows potential for significantly alleviating constipation symptoms by restoring gut microbiota balance in patients with PD.Despite promising developments,the causal relationship between changes in gut microbiota and PD-related constipation remains elusive,highlighting the need for further research in this expanding field.

关 键 词：Parkinson disease CONSTIPATION Gut microbiota PREBIOTICS PROBIOTICS Fecal microbiota transplantation 

分 类 号：R742.5[医药卫生—神经病学与精神病学]