Coca-Cola consumption vs fragmentation in the management of patients with phytobezoars:A prospective randomized controlled trial  

作　　者：Fu-Guo Liu De-Feng Meng Xia Shen Dan Meng Ying Liu Ling-Yun Zhang 

机构地区：[1]Department of Gastroenterology,The Affiliated Hospital of Qingdao University,Qingdao 266000,Shandong Province,China [2]Endoscopy Center,The Affiliated Hospital of Qingdao University,Qingdao 266000,Shandong Province,China

出　　处：《World Journal of Gastrointestinal Endoscopy》2024年第2期83-90,共8页世界胃肠内镜杂志（英文版）（电子版）

摘　　要：BACKGROUND Gastric phytobezoars(GPBs)are very common in northern China.Combined therapy involving carbonated beverage consumption and endoscopic lithotripsy has been shown to be effective and safe.Existing studies on this subject are often case reports highlighting the successful dissolution of phytobezoars through Coca-Cola consumption.Consequently,large-scale prospective investigations in this domain remain scarce.Therefore,we conducted a randomized controlled trial to examine the effects of Coca-Cola consumption on GPBs.AIM To evaluate the impact of Coca-Cola on GPBs,including the dissolution rate,medical expenses,ulcer rate,and operation time.METHODS A total of 160 consecutive patients diagnosed with GPBs were allocated into two groups(a control group and an intervention group)through computer-generated randomization.Patients in the intervention group received a Coca-Cola-based regimen(Coca-Cola 2000-4000 mL per day for 7 d),while those in the control group underwent emergency fragmentation.RESULTS Complete dissolution of GPBs was achieved in 100% of the patients in the intervention group.The disparity in expenses between the control group and intervention group(t=25.791,P=0.000)was statistically significant,and the difference in gastric ulcer occurrence between the control group and intervention group(χ^(2)=6.181,P=0.013)was also statistically significant.CONCLUSION Timely ingestion of Coca-Cola yields significant benefits,including a complete dissolution rate of 100%,a low incidence of gastric ulcers,no need for fragmentation and reduced expenses.

关 键 词：COCA-COLA BEZOARS SOLUBILITY LITHOTRIPSY Gastrosco 

分 类 号：R575.2[医药卫生—消化系统]