Pylephlebitis-induced acute liver failure: A case report and review of literature  

作　　者：Vera Hapshy Steven Imburgio Harshavardhan Sanekommu Brandon Nightingale Sobaan Taj Mohammad A Hossain Swapnil Patel 

机构地区：[1]Department of Internal Medicine,Jersey Shore University Medical Center,Neptune,NJ 07753,United States

出　　处：《World Journal of Hepatology》2024年第1期103-108,共6页世界肝病学杂志（英文版）（电子版）

摘　　要：BACKGROUND Pylephlebitis is an extremely rare form of septic thrombophlebitis involving the portal vein,carrying high rates of morbidity and mortality.CASE SUMMARY We present a case of a 42-year-old male with no past medical history who presented with acute onset of abdominal pain and altered mental status with laboratory tests demonstrating new-onset acute liver failure.Pylephlebitis was determined to be the underlying etiology due to subsequent workup revealing polymicrobial gram-negative anaerobic bacteremia and complete thrombosis of the main and left portal veins.To our knowledge,this is the first documented case of acute liver failure as a potential life-threatening complication of pylephlebitis.CONCLUSION Our case highlights the importance of considering pylephlebitis in the broad differential for abdominal pain,especially if there are co-existing risk factors for hypercoagulability.We also demonstrate that fulminant hepatic failure in these patients can potentially be reversible with the immediate initiation of antibiotics and anticoagulation.

关 键 词：Portal vein thrombosis Septic thrombophlebitis Gram negative anaerobic bacteremia PYLEPHLEBITIS Acute liver failure Case report 

分 类 号：R575.3[医药卫生—消化系统] R52[医药卫生—内科学]