Alterations of sleep deprivation on brain function:A coordinatebased resting-state functional magnetic resonance imaging metaanalysis  

作　　者：Qin Zhang Yong-Zhe Hou Hui Ding Yan-Ping Shu Jing Li Xi-Zhao Chen Jia-Lin Li Qin Lou Dai-Xing Wang 

机构地区：[1]Department of Radiology,The Second People’s Hospital of Guizhou Province,Guiyang 550000,Guizhou Province,China [2]Department of Radiology,Guizhou Provincial People’s Hospital,Guiyang 550000,Guizhou Province,China [3]Department of Psychiatry of Women and Children,The Second People’s Hospital of Guizhou Province,Guiyang 550000,Guizhou Province,China [4]Medical Humanities College,Guizhou Medical University,Guiyang 550000,Guizhou Province,China

出　　处：《World Journal of Psychiatry》2024年第2期315-329,共15页世界精神病学杂志

摘　　要：BACKGROUND Sleep deprivation is a prevalent issue that impacts cognitive function.Although numerous neuroimaging studies have explored the neural correlates of sleep loss,inconsistencies persist in the reported results,necessitating an investigation into the consistent brain functional changes resulting from sleep loss.AIM To establish the consistency of brain functional alterations associated with sleep deprivation through systematic searches of neuroimaging databases.Two metaanalytic methods,signed differential mapping(SDM)and activation likelihood estimation(ALE),were employed to analyze functional magnetic resonance imaging(fMRI)data.METHODS A systematic search performed according to PRISMA guidelines was conducted across multiple databases through July 29,2023.Studies that met specific inclusion criteria,focused on healthy subjects with acute sleep deprivation and reported whole-brain functional data in English were considered.A total of 21 studies were selected for SDM and ALE meta-analyses.RESULTS Twenty-one studies,including 23 experiments and 498 subjects,were included.Compared to pre-sleep deprivation,post-sleep deprivation brain function was associated with increased gray matter in the right corpus callosum and decreased activity in the left medial frontal gyrus and left inferior parietal lobule.SDM revealed increased brain functional activity in the left striatum and right central posterior gyrus and decreased activity in the right cerebellar gyrus,left middle frontal gyrus,corpus callosum,and right cuneus.CONCLUSION This meta-analysis consistently identified brain regions affected by sleep deprivation,notably the left medial frontal gyrus and corpus callosum,shedding light on the neuropathology of sleep deprivation and offering insights into its neurological impact.

关 键 词：Sleep deprivation Resting-state-functional magnetic resonance imaging Activation likelihood estimation-meta Signed differential mapping-meta 

分 类 号：R74[医药卫生—神经病学与精神病学]