Therapeutic sponge prevents postoperative breast cancer recurrence by sustainably dissociating into CD44-targeted nanoplatform  

作　　者：Junhui Sui Mingda Zhao Zhihao Guo Jiafeng Li Jie Chen Hongli Chen Jie Liang Yong Sun Xingdong Zhang Yujiang Fan 

机构地区：[1]National Engineering Research Center for Biomaterials,Sichuan University,Chengdu 610064,China [2]Beijing Tide Pharmaceutical Co.,Ltd.,Beijing 100176,China [3]The Key Laboratory of Biomedical Material,School of Life Science and Technology,Xinxiang Medical University,Xinxiang 453003,China [4]Coal Mining Branch,China Coal Research Institute,Beijing 100028,China [5]School of Ophthalmology&Optometry,Eye Hospital,Wenzhou Medical University,Wenzhou 325027,China

出　　处：《Nano Research》2024年第3期1792-1803,共12页纳米研究（英文版）

基　　金：sponsored by the National Natural Science Foundation of China(Nos.51973136 and 32071352);the Open Project Program of the Third Affiliated Hospital of Xinxiang Medical University(No.KFKTZD202102).

摘　　要：Locoregional recurrence and distant metastasis of breast cancer still pose a significant risk for patients’survival.To address the clinical challenge,functional absorbable sponges(HA-SH/PP-Dox/Lap/COL I(HCNPs))were constructed by biomimetic extracellular matrix of collagen I/hyaluronic acid complex conjugated with doxorubicin/lapatinib(Dox/Lap)-loaded nanoparticles.The HCNPs sponge exhibited excellent clotting ability and blood absorption rate.Worthily,Dox/Lap-loaded nanoparticles were synchronously endowed with a large number of oligo hyaluronic acid segments after degradation,which thus enhanced the ability of targeting into CD44-overexpressed tumor cells.The implantable HCNPs sponge in resected cavity of postoperative 4T1 models inhibited the spread of scattered tumor cells by absorbing the inevitable bleeding.More importantly,CD44 targeted nanoparticle with suitable Dox/Lap proportion continuously released from sponge to kill tumor cells of surrounding HCNPs and those remaining at surgical margin,thus prevented local recurrence as well as distant metastasis.Therefore,the functional HCNPs sponge might provide a safer and more effective strategy for postoperative treatment of cancer.

关 键 词：therapeutic sponge scattered tumor cells recurrence and metastasis CD44-targeted nanoparticles breast cancer 

分 类 号：R730.5[医药卫生—肿瘤]