Fibrillarin promotes homologous recombination repair by facilitating the recruitment of recombinase RAD51 to DNA damage sites  

作　　者：Yanhua MU Jinhua HAN Mingjie WU Zongfang LI Ke DU Yameng WEI Mengjie WU Jun HUANG 

机构地区：[1]National-Local Joint Engineering Research Center of Biodiagnosis&Biotherapy,The Second Affiliated Hospital of Xi'an Jiaotong University,Xi'an 710004,China [2]The MOE Key Laboratory of Biosystems Homeostasis&Protection and Innovation Centerfor Cell Signaling Network,Life Sciences Institute,Zhejiang University,Hangzhou 310058,China [3]Zhejiang Provincial Key Lab of Geriatrics and Geriatrics Institute of Zhejiang Province,Department of Geriatrics,Zhejiang Hospital.Hangzhou310030,China [4]Trauma Center,The First Afiliated Hospital,Zhejiang University School of Medicine,Hangzhou 310003,China [5]The Afiliated Hospitalof Stomatology,Schoolof Stomatology,Zhejiang University Schoolof Medicine,Key Laboratory of Oral Biomedical Research of Zhejiang Province,Hangzhou 310006,China [6]Zhejiang Provincial Key Labratoryof Cancer Molecular Cell Biology,Life Sciences Institute,Zhejiang University,Hangzhou 30058,China [7]Department of General Surgery,Sir Run Run Shaw Hospital,Zhejiang University School of Medicine,Hangzhou 310016,China

出　　处：《Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)》2023年第12期1165-1173,共9页浙江大学学报（英文版）B辑（生物医学与生物技术）

基　　金：supported by the National Key Research ar d Development Program of China(Nos.2022YFA 1302800 and 2021 YFA 1101000);the National Natural Science Foundation of China(Nos.31961160725,31730021,31971220,32270769,and 32170730);the Fok Ying Tung Education Foundation,the Fundamental Research Funds for the Provincial Universities of Zhejiang(No.2021XZZX039);the Natural Science Foundation of Shaanxi Province(No.2023-JC-QN-0942);the Research Fund of Xi'an Jiaotong University(No.YXJLRH2022098);the Research Fund of the Second A filiated Hospital of Xi an Jiaotong University(Nos.2020YJ(ZY TS)546-10;Y J(QN)202014),China.

摘　　要：Eukaryotic organisms constantly face a wide range of internal and external factors that cause damage to their DNA.Failure to accurately and efficiently repair these DNA lesions can result in genomic instability and the development of tumors(Canela et al.,2017).Among the various forms of DNA damage,DNA doublestrand breaks(DSBs)are particularly harmful.Two major pathways,non-homologous end joining(NHEJ)and homologous recombination(HR),are primarily responsible for repairing DSBs(Katsuki et al.,2020;Li and Yuan,2021;Zhang and Gong,2021;Xiang et al.,2023).NHEJ is an error-prone repair mechanism that simply joins the broken ends together(Blunt et al.,1995;Hartley et al.,1995).

关 键 词：damage HOMOLOGOUS 

分 类 号：Q81[生物学—生物工程]