口腔HPV感染的研究现状  

Current research status of oral human papillomavirus(HPV)infection

作　　者：侯政瑶 王可心 王庆梅 杨小琛 宋凯[2] HOU Zhengyao;WANG Kexin;WANG Qingmei;YANG Xiaochen;SONG Kai(Department of Obstetrics,Qingdao Hospital of Tradition-al Chinese Medicine(Qingdao Hiser Hospital),Qingdao 266033,China)

机构地区：[1]青岛大学附属海慈医院(青岛市中医医院)产科,山东青岛266033 [2]青岛大学附属医院口腔颌面外科,山东青岛266003

出　　处：《口腔医学》2024年第1期63-68,共6页Stomatology

基　　金：国家自然科学基金(81502340)。

摘　　要：流行病学证据表明口腔是人乳头瘤病毒(human papillomaviruses,HPV)的储存库,水平传播和垂直传播等多种途径促进了口腔HPV感染的流行。低危型HPV感染可能导致口腔黏膜良性病变,而高危型HPV的持续感染是诱发头颈部鳞状细胞癌的重要危险因素。目前,我国关于口腔HPV感染的研究工作并不深入,国人对相关知识的认知不足,这不利于相关疾病防治工作的开展。在此背景下,本文对口腔HPV感染的研究现状进行综述,以期为我国口腔HPV感染的防治工作提供参考。Epidemiologic evidences have demonstrated that the oral cavity is a reservoir for human papillomavirus(HPV).Multiple transmission routes including horizontal transmission and vertical transmission increase the incidence of oral HPV infection.Low⁃risk HPV may cause benign lesions of the oral mucosal,and persistent infection with high⁃risk HPV is an important risk factor for the devel⁃opment of head and neck squamous cell carcinoma.At present,the research on oral HPV infection in China is not in⁃depth,and Chi⁃nese people have insufficient understanding of relevant knowledge,which is not conducive to the development of related disease preven⁃tion and treatment.In this context,this article reviews the current research status of oral HPV infection,in order to provide reference for the prevention and treatment of oral HPV infection in China.

关 键 词：人乳头瘤病毒 疾病传播 口腔疾病 HPV疫苗 预防和控制 流行病学 发病机制 

分 类 号：R781.53[医药卫生—口腔医学]