MXene纳米材料在生物医学应用中促成骨的机制研究  

The osteogenic mechanism of MXene nanomaterials in biomedical applications

作　　者：朱昕妍 靳牧涵 严菁菁 王美琪 张一玲 马俊青[2] 袁俊[3] ZHU Xinyan;JIN Muhan;YAN Jingjing;WANG Meiqi;ZHANG Yiling;YUAN Jun;MA Junqing(School of Stomatology,Nanjing Medical University,Nanjing 210029,China)

机构地区：[1]南京医科大学口腔医学院,江苏南京210029 [2]南京医科大学附属口腔医院正畸科,江苏南京210029 [3]南京医科大学附属口腔医院第四门诊部,江苏南京210029

出　　处：《口腔医学》2024年第1期75-80,共6页Stomatology

基　　金：江苏省口腔疾病研究重点实验室开放项目(JSKLOD⁃KF⁃2102);江苏省大学生创新创业省级重点项目(202210312013Z);江苏省科教能力提升工程——江苏省研究型医院(YJXYYJSDW4),江苏省医学创新中心(CXZX202227)。

摘　　要：MXene纳米复合材料是一种新兴的生物活性材料,它具有良好的理化性能和生物相容性,已被用于各类组织工程和再生的研究。目前发现MXene纳米复合材料能够促进成骨相关细胞的黏附、增殖和分化,调控成骨相关基因和蛋白的表达和相关信号通路,促进缺损部位血管生成,从而促进骨缺损修复。这使其成为骨组织再生领域的热门研究材料。本文就MXene纳米复合材料促进骨再生作用的具体机制进行综述,为其基础及临床研究应用提供理论依据和新思路。MXene nanocomposites are an emerging bioactive material with good physicochemical properties and biocompatibility,and have been used in various studies on tissue engineering and regeneration.MXene nanocomposites have been found to promote the adhe⁃sion,proliferation and differentiation of osteogenic⁃related cells,regulate the expression of osteogenic⁃related genes and proteins,mod⁃ulate related signaling pathways,and promote angiogenesis at the defect site,thereby facilitating the repair of bone defects.This makes it a popular research material in bone tissue regeneration.In this paper,we review the specific mechanism of MXene nanocomposites in promoting bone regeneration to provide a theoretical basis and new ideas for its application in basic and clinical research.

关 键 词：MXene 骨再生 组织工程 

分 类 号：R783.1[医药卫生—口腔医学]