人工肝治疗的临床实践与研究进展  

Clinical practice and research advances in artificial liver support therapy

作　　者：韩涛[1] 张倩[1] HAN Tao;ZHANG Qian(Department of Gastroenterology and Hepatology,Tianjin People’s Hospital,Tianjin Union Medical Center Affiliated to Nankai University,Tianjin 300121,China)

机构地区：[1]南开大学人民医院,天津市人民医院消化(肝病)科,天津300121

出　　处：《临床肝胆病杂志》2024年第2期225-228,共4页Journal of Clinical Hepatology

摘　　要：人工肝支持系统是治疗肝衰竭的重要方法之一,近年来非生物型人工肝在肝衰竭救治中的作用越来越受到认可,在非肝衰竭疾病中的应用也日益广泛。临床上需要综合多种因素,合理选择非生物型人工肝治疗的时机及模式,规范化、个体化、精准化治疗及不同模式的优化组合是人工肝临床应用的趋势。生物型人工肝有关种子细胞来源、生物反应器等关键技术不断完善,且部分已经进入临床试验阶段。尽管人工肝治疗的临床实践与研究已取得很大进展,但仍面临不少挑战。如何通过技术创新与优化组合进一步提高其疗效与安全性,如何通过高质量的临床试验获得更高级别循证医学证据,仍是目前亟需解决的难题。Artificial liver support system is one of the important therapies for liver failure,and in recent years,the role of nonbioartificial liver support system in the treatment of liver failure has been gradually recognized,with wide application in non-liver failure diseases.In clinical practice,various factors should be considered to reasonably select the timing and mode of nonbioartificial liver support therapy,and standardized,individualized,and precise treatment and optimal combination of different modes are the trend of the clinical application of artificial liver support therapy.There have been constant improvements in the key techniques of bioartificial liver support system such as seed cell source and bioreactor,and some of them have entered the stage of clinical trial.Although remarkable progress has been made in the clinical practice and research of artificial liver support therapy,there are still many challenges,and it is urgently needed to solve the problems of how to further improve its efficacy and safety through technological innovation and combination optimization and how to obtain higher-level evidence-based medical evidence through high-quality clinical trials.

关 键 词：肝 人工 肝功能衰竭 治疗学 

分 类 号：R575.3[医药卫生—消化系统]