非生物型人工肝技术的优化与生物型人工肝研究进展  

Optimization of non-bioartificial liver technology and research advances in biological artificial liver

作　　者：周莉[1] 杨颜榕 陈煜[1] ZHOU Li;YANG Yanrong;CHEN Yu(Beijing Municipal Key Laboratory of Liver Failure and Artificial Liver Treatment Research,Forth Department of Liver Disease Center/Difficult and Complicated Liver Diseases and Artificial Liver Center,Beijing YouAn Hospital,Capital Medial University,Beijing 100069,China)

机构地区：[1]首都医科大学附属北京佑安医院肝病中心四科(疑难肝病及人工肝中心),肝衰竭与人工肝治疗研究北京市重点实验室,北京100069

出　　处：《临床肝胆病杂志》2024年第2期239-245,共7页Journal of Clinical Hepatology

基　　金：国家重点研发计划项目(2022YFC2304400);北京市医院管理中心“登峰”人才培养计划(DFL20221501);高层次公共卫生技术人才培养计划(2022-2-012);北京市科技新星计划(20220484201)。

摘　　要：肝衰竭是临床常见综合征,进展快速,预后不良。目前其内科治疗方法仍有限,人工肝治疗是一种有效的治疗方法。非生物型人工肝技术在临床上广泛应用,其具体的启动时机、模式的选择、参数的设置需要临床医生根据疾病的病理生理机制及动态演变过程,结合患者具体情况决定。与非生物型人工肝相比,生物型人工肝能更好地模拟肝细胞的生物学功能,目前其核心技术已取得实质性的进展,相关临床研究也在积极进行,在未来有广阔的发展前景。本文就非生物型人工肝技术的优化及生物型人工肝相关进展进行总结与探讨,以期为人工肝技术的临床应用与研究提供参考。Liver failure is a common clinical syndrome with rapid progression and poor prognosis.Currently,there are still limited internal medical treatment methods for liver failure,and artificial liver support therapy is an effective treatment method.Nonbioartificial liver technology is widely used in clinical practice,and clinicians should determine the starting time,mode,and specific parameters of treatment according to the pathophysiological mechanism and dynamic evolution process of the disease,as well as the specific conditions of patients.Compared with non-bioartificial liver,biological artificial liver can better simulate the biological function of liver cells.At present,substantial progress has been made in its core technology,and related clinical studies are being conducted actively,suggesting a vast potential for future development.This article summarizes and discusses the optimization of non-bioartificial liver technology and the advances in biological artificial liver,in order to provide a reference for the clinical application and research of artificial liver technology.

关 键 词：肝 人工 肝功能衰竭 治疗学 

分 类 号：R575.3[医药卫生—消化系统] R318.14[医药卫生—内科学]