孟德尔随机化在肝癌研究中的应用  

Application of Mendelian randomization in liver cancer

作　　者：李凌巍 秦俊杰[1] 贾云龙 吕浩[2] LI Lingwei;QIN Junjie;JIA Yunlong;LYU Hao(Department of Gastroenterology,The First Hospital of Jilin University,Changchun 130021,China;Department of Emergency Medicine,Lequn Branch,The First Hospital of Jilin University,Changchun 130021,China)

机构地区：[1]吉林大学第一医院乐群院区消化内科,长春130021 [2]吉林大学第一医院乐群院区急救医学科,长春130021

出　　处：《临床肝胆病杂志》2024年第2期391-396,共6页Journal of Clinical Hepatology

基　　金：吉林省财政厅项目(JLSWSRCZX2020-049)。

摘　　要：近年来,基于全基因组关联研究的孟德尔随机化研究方法被广泛应用于医学领域的病因探索,以其遗传变异的分配随机性和时序优先性的独特优势,可以有效克服传统观察性研究中的混杂偏倚和反向因果的干扰。本文针对该方法及其在肝癌研究领域的应用进展作一综述,旨在为肝癌的因果关联研究提供新思路。In recent years,the research method of Mendelian randomization based on genome-wide association studies has been widely used for etiological exploration in the medical field,which can effectively overcome the confounding biases and interference of reverse causalities in traditional observational researches with its unique advantages of the distributive randomness and timing priority of genetic variants.This article reviews the method of Mendelian randomization and its application in liver cancer,in order to provide new ideas for the research on causal association in liver cancer.

关 键 词：孟德尔随机化分析 肝肿瘤 全基因组关联研究 

分 类 号：R735.7[医药卫生—肿瘤]