去乙酰化酶Sirtuins家族与放射性肝病的关系  

Association between deacetylase Sirtuins and radiation-induced liver disease

作　　者：宗也凯 刘江凯[2] ZONG Yekai;LIU Jiangkai(The First Clinical Medical College of Henan University of Chinese Medicine,Zhengzhou 450008,China;Spleen,Stomach and Hepatobiliary Department,The First Affiliated Hospital of Henan University of Chinese Medicine,Zhengzhou 450008,China)

机构地区：[1]河南中医药大学第一临床医学院,郑州450008 [2]河南中医药大学第一附属医院脾胃肝胆科,郑州450008

出　　处：《临床肝胆病杂志》2024年第2期419-425,共7页Journal of Clinical Hepatology

基　　金：国家自然科学基金(U1504825);河南省中医药拔尖人才项目(CZ20262-19);河南省特色骨干学科中医学学科建设项目(STG-ZYX04-202133)。

摘　　要：放射性肝病(RILD)或称放射性肝炎,是一种由辐射引起的亚急性肝损伤。去乙酰化酶家族Sirtuins(SIRTs)作为衰老相关研究的焦点具有DNA修复和染色质调节等分子功能,是基因组和表观基因组稳定性的枢纽。辐射诱导的肝脏DNA损伤和反应是RILD主要的生理病理过程,这与SIRTs表征的功能相似。本文简述了SIRTs蛋白家族的结构和功能,回顾了放射治疗的物理生理学基本概念及进展,主要从放射生物学角度分析了SIRTs与RILD二者的内在关系,指出SIRTs作为RILD防治靶点的可能性。Radiation-induced liver disease(RILD),also known as radiation hepatitis,is subacute liver injury induced by radiation.As the focus of senescence-related studies,the deacetylase family Sirtuins(SIRTs)have the molecular functions including DNA repair and chromatin regulation,which makes SIRTs a hub for regulating genome and epigenome stability.Radiation-induced hepatic DNA damage and reaction is the primary physiological and pathological process of RILD,which is similar to the function of SIRTs.This article briefly introduces the structure and function of the SIRTs protein family,elaborates on the basic concepts and progress of the physical physiology of radiation therapy,discusses the internal relationship between SIRTs and RILD from the perspective of radiobiology,and points out the possibility of SIRTs as a target for the prevention and treatment of RILD.

关 键 词：放射性肝病 抗衰老酶 辐射 电离 

分 类 号：R575.5[医药卫生—消化系统]