Logopenic变异型原发性进行性失语病例报道1例  

A case of Logopenic variant primary progressive aphasia was reported and reviewed

作　　者：叶青青 乐欢 唐娥 刘净娇 刘庆[1] Qingqing YE;Huan LE;E TANG;Jingjiao LIU;Qing LIU(The Second People's Hospital of Guiyang City(Jinyang Hospital)of Guizhou Province/Jinyang Hospital Affiliated to Guizhou Medical University,Guiyang 550000,China)

机构地区：[1]贵州省贵阳市第二人民医院(金阳医院)/贵州医科大学附属金阳医院,贵阳550000

出　　处：《阿尔茨海默病及相关病杂志》2024年第1期35-39,共5页Chinese Journal of Alzheimer's Disease and Related Disorders

摘　　要：目的:Logopenic变异型原发性进行性失语(logopenic variant primary progressive aphasia,lvPPA)临床较为少见,大部分lvPPA与阿尔茨海默病(Alzheimer's disease,AD)具有典型的病理改变,相较以记忆障碍起病的典型AD,以非遗忘综合征起病的不典型AD容易被误诊或漏诊。分享1例以非流利型口语障碍为首发症状的不典型AD-Logopenic变异型原发性进行性失语患者,以期为临床医生提供非典型AD的临床诊治经验。方法:报告1例非典型阿尔茨海默病lvPPA患者的临床、影像学、实验室检查等特点,并结合文献进行复习。结果:早非典型AD-Logopenic变异型原发性进行性失语主要表现为早期出现的自发语言和命名过程中单个词语的取词困难及语句复述能力下降。详细地询问病史,体格检查,及生物标记物的检测、PET或基因检测可助于早期诊断。Objective:Logopenic variant primary progressive aphasia(lvPPA)is rare neurodegenerative disease,and characterized by a progressive impairments of specific language functions.More recently studies have shown that some cases have underlying Alzheimer’s disease pathology.the atypical AD with non-amnesic syndrome is more likely to be misdiagnosed and missed.we report a case with a logopenic variant of primary progressive aphasia with non-fluent dyslexia as the initial symptom.The description of this case provide clinical experience in the diagnosis and treatment of atypical AD.Methods:We detail the whole clinical course,including its neurolinguistic study,magnetic resonance imaging(MRI),and treatment.In addition,we reviewed the literature and provide a summary of the characteristics,complications,treatment,and prognosis of these cases.Results:The primary progressive aphasia of early atypical AD-Logopenic variant was characterized by early spontaneous speech and difficulty in picking.

关 键 词：原发性进行性失语症 非典型阿尔茨海默病 临床特点 言语障碍 神经影像 诊断标准 

分 类 号：R749.16[医药卫生—神经病学与精神病学]