参仙汤对气阴两虚型非小细胞肺癌患者免疫功能及生活质量的影响  

Clinical study on the effect of Shenxian Decoction on immune function and quality of life in patients with non-small cell lung cancer of deficiency of both Qi and Yin

作　　者：张红颖 马骏[1] 吴艾平[1] 张雨 ZHANG Hongying;MA Jun;WU Aiping;ZHANG Yu(Department of Oncology,Huai′an TCM Hospital Affiliated to Nanjing University of Chinese Medicine,Huai′an 223001,Jiangsu,China)

机构地区：[1]南京中医药大学附属淮安中医院肿瘤科,江苏淮安223001

出　　处：《西部医学》2024年第1期85-90,共6页Medical Journal of West China

基　　金：江苏省中医药科技发展计划项目(YB201967)。

摘　　要：目的 观察参仙汤对肺癌化疗患者免疫功能及生活质量影响。方法 收集我院2020年3月30日—2022年8月10日需要化疗的非小细胞癌患者66例,脱落2例,完成64例。分为试验组(参仙汤联合化疗)33例及对照组(参仙汤模拟剂联合化疗)31例。对照组予以TP、GP、DP、PC化疗方案为基础治疗,共2周期,每周期间隔21 d,同时在化疗首日加用参仙汤模拟剂口服;试验组在对照组化疗方案基础上加用参仙汤口服,连续服用2周期,共42 d。入组前3天内、第1周期及第2周期治疗完成后1周内测定淋巴细胞亚群及生活质量评分。结果 每个周期治疗结束后,试验组CD3^(+)细胞/淋巴细胞、CD3^(+)CD4^(+)细胞/淋巴细胞、CD3^(+)CD8^(+)细胞/淋巴细胞高于对照组,差异有统计学意义(P<0.05);试验组B细胞/淋巴细胞在第2周期治疗结束后高于对照组,差异有统计学意义(P<0.05)。治疗结束后,试验组在整体生活质量、躯体功能、社会功能、疲劳、气促、失眠、咳嗽、咯血、呼吸困难方面较对照组有改善,差异均具有统计学意义(P<0.05)。结论 参仙汤可增强肺癌患者免疫功能、提高生活质量、减轻化疗相关毒副反应且未见明显毒副反应。Objective To observe the effect of Shenxian Decoction on immune function and quality of life of patients with lung cancer.Methods A total of 66 patients with non-small cell lung cancer requiring chemotherapy were enrolled,64 of whom were completed.They were divided into the test group(Shenxian Decoction combined with chemotherapy,33 cases) and the control group(Shenxian Decoction mimics combined with chemotherapy,31 cases).The control group was treated with TP,GP,DP and PC chemotherapy regimen as the basic treatment,with a total of 2 cycles,21 days every cycle.Shenxian Decoction was added to the first day of chemotherapy.The experimental group took Shenxian Decoction orally on the basis of the chemotherapy regimen of the control group for 2 consecutive cycles,a total of 42 days.Lymphocyte subsets and quality of life scores were measured within 3 days before enrollment,within 1 week after the completion of the first and second cycles of treatment.Results After the end of each cycle of treatment,the CD3^(+)cells/lymphocytes,CD3^(+)CD4^(+)cells/lymphocytes,and CD3^(+)CD8^(+)cells/lymphocytes in the test group were higher than those in the control group,and the difference was statistically significant(P<0.05).B cells/lymphocytes in the test group were higher than those in the control group after the end of the second cycle of treatment(P<0.05).After treatment,the overall quality of life,physical function,role function,social function,fatigue,shortness of breath,insomnia,cough,hemoptysis and dyspnea of the test group were improved compared with those of the control group,and the difference were statistically significant(P<0.05).Conclusion Shenxian Decoction can enhance the immune function of patients with lung cancer,improve the quality of life,reduce the toxic and side effects related to chemotherapy,and with a safety reliability.

关 键 词：参仙汤 肺癌 免疫功能 生活质量 临床研究 

分 类 号：R734.2[医药卫生—肿瘤]