马来酸氟伏沙明片联合直流电刺激对精神分裂症患者睡眠质量及神经功能的影响  

Effects of fluvoxamine maleate tablets combined with direct current stimulation on sleep quality and neurological function in patients with schizophrenia

作　　者：米莉 李娟[1] 刘兴康 MI Li;LI Juan;LIU Xingkang(Department of Chronic Mental Rehabilitation,Chengdu Fourth People′s Hospital,Chengdu 610036,China)

机构地区：[1]成都市第四人民医院慢性精神康复科,四川成都610036

出　　处：《西部医学》2024年第1期130-134,共5页Medical Journal of West China

基　　金：成都市医学科研课题(2021420)。

摘　　要：目的 分析马来酸氟伏沙明片联合直流电刺激对精神分裂症患者睡眠质量及神经功能的影响。方法 选取本院2020年5月-2021年5月进行精神分裂症治疗的患者80例,通过随机对照患者分为对照组和研究组,每组各40例。对照组给予直流电刺激进行治疗;研究组给予马来酸氟伏沙明片联合直流电刺激进行治疗。采用阳性和阴性症状量表(PANSS)评定患者精神分裂症临床症状情况;采用认知功能成套测验(MCCB)评分量表、个人和社会功能量表(PSP)评定患者认知功能、社会功能;采用匹茨堡睡眠质量指数量表(PSQI)评定患者睡眠质量;采用酶联免疫吸附试验法检测5-羟色胺(5-HT)、多巴胺(DA)、去甲肾上腺素(NE)水平,对比两组治疗效果。结果 治疗后,与对照组相比,研究组PANSS评分、睡眠质量评分水平均降低(P<0.05);研究组MCCB、PSP评分、5-HT、DA、NE水平均升高(P<0.05);研究组总有效率较高(P<0.05)。结论 经马来酸氟伏沙明片联合直流电刺激治疗后,精神分裂症患者睡眠质量显著提升,神经功能显著改善,认知功能、社会功能也得到显著提升,临床治疗效果显著。Objective To analyze the effects of fluvoxamine maleate tablets combined with direct current stimulation on sleep quality and neurological function in patients with schizophrenia.Methods A total of 80 patients with schizophrenia who were treated in our hospital from May 2020 to May 2021 were selected,and the 80 patients were randomly divided into the control group and the study group,with 40 cases in each.The control group was treated with direct current stimulation;the study group was treated with fluvoxamine maleate tablets combined with direct current stimulation.The Positive and Negative Symptom Scale(PANSS) was used to evaluate the clinical symptoms of patients with schizophrenia;the Cognitive Function Test Panel(MCCB) scoring scale,the Personal and Social Function Scale( Personal and Social Functioning Scale,PSP) was used to evaluate patients′ cognitive function and social function;Pittsburgh sleep quality index(PSQI) was used to evaluate patients′ sleep quality;enzyme-linked immunosorbent assay was used to detect serotonin(5-hydroxytryptamine) The levels of hydroxytryptamine(5-HT),dopamine(DA) and norepinephrine(NE) were compared between the two groups.Results After treatment,compared with the control group,the PANSS score and sleep quality score of the study group were decreased(P<0.05),the levels of MCCB,PSP,5-HT,DA,and NE in the study group were all increased(P<0.05).The total effective rate of the study group was higher than that of the control group(P<0.05).Conclusion After fluvoxamine maleate tablets combined with direct current stimulation treatment,the sleep quality of patients with schizophrenia is significantly improved,the neurological function is significantly improved,the cognitive function and social function are also significantly improved,and the clinical treatment effect is remarkable.

关 键 词：精神分裂症 马来酸氟伏沙明片 直流电刺激 睡眠质量 神经功能 

分 类 号：R749.3[医药卫生—神经病学与精神病学]