粪便胆汁酸与慢性回肠末端炎症程度呈正相关:一项前瞻性队列研究  

Fecal bile acids is positively correlated with the severity of chronic terminal ileitis:a prospective cohort study

作　　者：余水岸 李跃[1] YU Shui-an;LI Yue(Department of Gastroenterology,Nanfang Hospital Southern Medical University,Guangzhou 510515,China)

机构地区：[1]南方医科大学南方医院消化内科

出　　处：《现代消化及介入诊疗》2023年第10期1214-1217,共4页Modern Interventional Diagnosis and Treatment in Gastroenterology

基　　金：广东省东莞市社会发展科技项目(20211800903122)。

摘　　要：目的 探讨粪便胆汁酸在慢性末端回肠炎中的意义。方法 前瞻性地纳入2021年10月至2023年5月就诊的慢性末端回肠炎患者及健康人群,分别为作为病例组和健康对照组,每组90例。通过独立样本T检验比较病例组临床评分及检测2组粪便胆汁酸及其组分水平。结果 与健康组相比,病例组的粪便中总胆汁酸(TBA)含量显著增加(t=-57.699,df=179,P<0.001);病例组根据临床评分分为轻度、中度及重度3个亚组,亚组临床评分与TBA水平正相关(r=0.571,P<0.001)。其中胆酸(CA)和鹅去氧胆酸(CDCA)的含量增加,石胆酸(LCA)的含量减少,这两者的差异均具有统计学意义(P<0.001)。结论 粪便胆汁酸与慢性回肠末端炎症程度呈正相关,测定粪便胆汁酸可为慢性末端回肠炎患者提供一种疾病评估的新方法。Objective To explore the significance of fecal bile acids in chronic terminal ileitis.Methods Patients with chronic terminal ileitis and healthy individuals who sought medical treatment from October 2021 to May 2023 were prospectively included in the case group and the healthy control group respectively.There were 90 cases in each group.Independent sample t test was used to compare the clinical scores of the case group and detect the levels of fecal bile acids and their components in the two groups.Results Compared with the healthy group,the content of total bile acids(TBA)in feces of the case group increased significantly(t=-57.699,df=179,P<0.001);According to the clinical score,the case group was divided into three subgroups:mild,moderate and severe,and the clinical score of subgroups was positively correlated with TBA level(r=0.571,P<0.001).The result showed that the content of cholic acid(CA)and chenodeoxycholic acid(CDCA)increased,while the content of lithocholic acid(LCA)decreased and the differences were statistically significant(P<0.001).Conclusion Fecal bile acids is positively correlated with the severity of chronic terminal ileitis.Determination of fecal bile acids can provide a new method for disease assessment of patients with chronic terminal ileitis.

关 键 词：粪便胆汁酸 慢性末端回肠炎 CTI 

分 类 号：R574.53[医药卫生—消化系统]