血清OPN、sPD-L1、miR-370在急性髓系白血病中的表达及与危险分层的关系  

Expression of serum OPN,sPD-L1 and miR-370 in acute myeloid leukemia and their relationship with risk stratification

作　　者：刘冰[1] 王舒[2] 杨莹[2] LIU Bing;WANG Shu;YANG Ying(Department of Hematology,The Second People's Hospital of Nanyang City,Nanyang,Henan 473000,China)

机构地区：[1]河南省南阳市第二人民医院血液科,473000 [2]河南省南阳市第二人民医院血液淋巴瘤科,473000

出　　处：《淮海医药》2024年第1期13-16,21,共5页Journal of Huaihai Medicine

摘　　要：目的:分析血清骨桥蛋白(OPN)、可溶性程序性死亡因子配体-1(sPD-L1)、微小RNA-370(miR-370)在急性髓系白血病(AML)中的表达及与危险分层的关系。方法:选取2021年11月—2023年2月本院诊治的79例AML患者作为研究对象,根据相关标准分为低危组(n=26)、中危组(n=39)及高危组(n=14)。比较3组治疗前后血清OPN、sPD-L1、miR-370、白细胞计数(WBC)、血红蛋白(Hb)水平,采用Pearson分析血清OPN、sPD-L1、miR-370水平与WBC、Hb水平相关性,采用受试者工作特征曲线(ROC)分析治疗前血清OPN、sPD-L1、miR-370水平联合检测对AML患者危险分层情况的诊断价值。结果:3组治疗前后血清OPN、sPD-L1、miR-370、WBC水平比较:低危组<中危组<高危组(P<0.05);血清Hb水平比较:低危组>中危组>高危组(P<0.05);治疗前后血清OPN、sPD-L1、miR-370水平与WBC水平呈正相关(治疗前:r=0.637、0.629、0.661,治疗后:r=0.432、0.422、0.544,P<0.05),与Hb水平呈负相关(治疗前:r=-0.655、-0.648、-0.646,治疗后:r=-0.519、-0.507、-0.438,P<0.05);治疗前血清OPN、sPD-L1、miR-370联合检测诊断AUC为0.942,高于单一检测(P<0.05)。结论:血清OPN、sPD-L1、miR-370水平与AML患者病情程度、分层情况密切相关,可为临床诊疗提供参考。Objective:To analyze the expression of serum osteopontin(OPN),soluble programmatic death factor ligand-1(sPD-L1) and micrornA-370(miR-370) in acute myeloid leukemia(AML)and their relationship with risk stratification.Methods:79 patients with AML treated in our hospital from November 2021 to February 2023 were selected as the study objects,and were divided into a low-risk group(n=26),a medium-risk group(n=39) and a high-risk group(n=14).Serum OPN,sPD-L1,miR-370,white blood cell count(WBC) and hemoglobin(Hb) levels were compared among the three groups before and after treatment.Pearson was used to analyze the correlation of serum levels of OPN,sPD-L1,miR-370 with the levels of WBC and Hb,and receiver operating characteristic curve(ROC) was used to analyze the combined detection value of serum OPN,sPD-L1,and miR-370 levels before treatment for risk stratification in AML patients.Results:The levels of serum OPN,sPD-L1,miR-370 and WBC before and after treatment were compared among the three groups:low risk groupmedium-risk group>high-risk group(P<0.05).Serum OPN,sPD-L1,miR-370 levels were positively correlated with WBC levels before and after treatment(before treatment:r=0.637,0.629,0.661;after treatment:r=0.432,0.422,0.544,P<0.05),and negatively correlated with Hb levels(before treatment:r=-0.655,-0.648,-0.646;after treatment:r=-0.519,-0.507,-0.438,P<0.05).The serum AUC before treatment was 0.942 in the combined diagnosis detection of OPN,sPD-L1,and miR-370,higher than the single detection(P<0.05).Conclusion:The serum levels of OPN,sPD-L1,and miR-370 are closely related to the severity and stratification of the disease,and can serve as a reference for clinical diagnosis and treatment.

关 键 词：急性髓系白血病 骨桥蛋白 可溶性程序性死亡因子配体-1 微小RNA-370 危险分层 

分 类 号：R733.71[医药卫生—肿瘤]