揿针对眼压控制后青光眼视功能改善的多中心随机双盲对照临床研究  

A multi-centre randomised double-blind controlled clinical study of press-needle for the improvement of visual function in patients with glaucoma after intraocular pressure control

作　　者：刘红佶 代艳[1] 余敏[1] 曾健[1] 王超 谭萨 张然[1] 余雪萌 谭凤 Liu Hongji;Dai Yan;Yu Min;Zeng Jian;Wang Chao;Tan Sa;Zheng Ran;Yu Xuemeng;Tan Feng(Mianyang Central Hospital,Mianyang,Sichuan,621000;Mianyang Chinese Medicine Hospital,Mianyang,Sichuan,621053;Mianyang Wanjiang Eye Hospital,Mianyang,Sichuan,621052)

机构地区：[1]绵阳市中心医院,四川绵阳621000 [2]绵阳中医医院,四川绵阳621053 [3]绵阳万江眼科医院,四川绵阳621052

出　　处：《中医眼耳鼻喉杂志》2024年第1期21-24,共4页Journal of Chinese Ophthalmology and Otorhinolaryngology

基　　金：四川省科学技术厅项目(NO.2021YJ0443);国家自然科学基金项目(NO.82305324);绵阳市中心医院孵化课题(2020FH07)。

摘　　要：目的 观察揿针对眼压控制后青光眼患者视功能的影响。方法 采用前瞻性、多中心、随机对照临床研究,从各中心选取192例眼压控制后青光眼患者,随机分为揿针组及安慰针组,分别予以揿针、安慰针治疗。比较治疗前、治疗后2月及4月BCVA、眼压、MD、MS、RNFL。结果 治疗前两组间BCVA、眼压、MD与MS、RNFL无差异(P>0.05)。治疗后2月及4月,安慰针组BCVA较治疗前明显降低(P<0.05),揿针组BCVA却未下降(P>0.05)。治疗后2月及4月,两组眼压无变化(P>0.05)。治疗后4月,安慰针组MS、MD较治疗前明显下降(P<0.05),揿针组却未下降(P>0.05)。治疗后4月,安慰针组RNFL较治疗前下降(P<0.05),而揿针组RNFL却较治疗前无差异(P>0.05),且揿针组RNFL明显高于安慰针组(P<0.05)。结论 揿针可延缓眼压控制后青光眼患者视力下降及视网膜纤维层变薄,以改善眼压控制后青光眼患者视功能。Objective To observe the effect of press-needle on visual function in glaucoma patients after intraocular pressure control.Methods A prospective,multicentre,randomised controlled clinical study was conducted on 192 glaucoma patients after IOP control,recruited from each centre,all the patients were randomly divided into the press-needle group and placebo-needle group.The press-needle group was treated with press-needle acupuncture,and the placebo-needle group with placebo-needle acupuncture.The best-corrected visual acuity(BCVA),intraocular pressure(IOP),visual field(mean defect(MD),mean sensitivity(MS)),and mean retinal fibre layer(RNFL)thickness were compared between the two groups before treatment,at 2 months after treatment,and at 4 months after treatment.Results There were no statistically differences in BCVA,IOP,MD,MS and RNFL between the two groups before treatment(P>0.05).At 2 and 4 months after treatment,BCVA in the placebo group was significantly lower than that before treatment(P<0.05),the BCVA of the press-needle group did not decline(P>0.05).At 2 and 4 months after treatment,there was no difference in IOP between the two group(P>0.05).At 4 months after treatment,MS and MD in the placebo-needle group decreased significantly compared with the pre-treatment period(P<0.05),while there was no significant difference in the press-needle group compared with the pre-treatment period(P>0.05).At 4 months after treatment,the RNFL in the placebo needle group decreased significantly compared with that before treatment(P<0.05),while there was no significant difference in the press-needle group compared with that before treatment(P>0.05),and the RNFL in the press-needle group was significantly greater than that in the placebo-needle group(P<0.05).Conclusion Press-needle can delay visual acuity loss and retinal fibre layer thinning in patients with glaucoma after IOP control,to improve visual function in patients with glaucoma after IOP control.

关 键 词：青光眼 揿针 视功能 随机对照研究 

分 类 号：R77[医药卫生—眼科]