头颈肿瘤发生、发展与外泌体环状RNA表达的相互作用机制  

Research on the mechanism of interaction between the occurrence and development of head and neck cancer and the expression of exosomal circular RNA

作　　者：封宇 付瑞俊 李茂才 堵永娅 李连庆[1] 宫丽丽[1] Feng Yu;Fu Ruijun;Li Maocai;Du Yongya;Li Lianqing;Gong Lili(Department of Otorhinolaryngology Head and Neck Surgery,Liaocheng People’s Hospital,Liaocheng 252000,China;Shandong First Medical University(Shandong Academy of Medical Sciences),Jinan 250000,China;Department of Surgery,Qiaoshan Town Health Center,Rizhao 276523,China;Department of Otorhinolaryngology Head and Neck Surgery,Liaocheng Dongchangfu People′s Hospital,Liaocheng 252024,China)

机构地区：[1]聊城市人民医院耳鼻咽喉头颈外科,聊城252000 [2]山东第一医科大学(山东省医学科学院),济南250000 [3]日照市莒县峤山镇卫生院外科,日照276523 [4]聊城市东昌府人民医院耳鼻咽喉头颈外科,聊城252024

出　　处：《国际耳鼻咽喉头颈外科杂志》2024年第1期37-40,共4页International Journal of Otolaryngology-Head and Neck Surgery

摘　　要：外泌体是由机体活细胞分泌的磷脂双层膜小囊泡,其可作为封装和转移环状RNA(circular RNA,circRNA)等多种功能性分子的载体。外泌体通过传递多种生物信号分子,在人类恶性肿瘤的发生发展中起着关键的调控作用,成为细胞间信息交流的重要介质。circRNA是一种非编码RNA,含有大量miRNA的结合位点,调控下游基因的表达,在疾病调控中发挥重要作用。头颈恶性肿瘤早期发现并治疗可以显著提高生存率,是降低死亡率的重要措施。本文就外泌体circRNA在头颈恶性肿瘤中的发生及转移做一综述。

关 键 词：头颈部肿瘤 肿瘤微环境 外泌体 环状RNA 

分 类 号：R739.91[医药卫生—肿瘤]