染色体外环状DNA在前列腺癌诊疗中的研究进展  

New progress of extrachromosomal circular DNA in the diagnosis and treatment of prostate cancer

作　　者：骆佳欣 朱一萌 郭兴朋 戚航铭 罗茵然 文荣琪 李晶 张珊 LUO Jiaxin;ZHU Yimeng;GUO Xingpeng;QI Hangming;LUO Yinran;WEN Rongqi;LI Jing;ZHANG Shan(Department of Bioinformatics,Center for Translational Medicine,Naval Medical University,Shanghai,200433,China)

机构地区：[1]海军军医大学转化医学研究中心生物信息学研究室,上海200433

出　　处：《临床泌尿外科杂志》2024年第1期58-64,共7页Journal of Clinical Urology

基　　金：国家自然科学基金面上项目(No:82372719)。

摘　　要：前列腺癌是西方国家中老年男性高发的一种恶性肿瘤。在中国,前列腺癌的患病率和发病率逐年上升,给社会带来了沉重的医疗负担。染色体外环状DNA(extrachromosomal circular DNA,eccDNA)被认为是前列腺癌的重要驱动因素,并与患者较差的预后相关。eccDNA不仅可以作为扩增癌基因的载体,还可以充当其他染色体外DNA或染色体上基因的增强子。本文综述了不同类型eccDNA的分子特征、功能和检测方法,并重点关注eccDNA在前列腺癌发生发展、肿瘤诊断和肿瘤耐药研究中的进展。此外,还讨论了eccDNA作为前列腺癌潜在诊断生物标志物和治疗靶点的作用。Prostate cancer is a malignancy with a high incidence among middle-aged and elderly men in Western countries.In China,the escalating incidence and prevalence over the years have imposed a significant burden on the healthcare system and society.Extrachromosomal circular DNA(eccDNA)plays a critical role in prostate cancer and is associated with poorer patient prognosis.Not only does eccDNA serve as a vehicle for amplifying oncogenes,it also can act in trans as an enhancer for genes on other eccDNA or chromosomes.In this review,we provide a concise overview of the molecular characteristics,functions,and detection methods about eccDNA of different types,with a particular focus on the advancement of eccDNA in development and progression of prostate cancer,tumor diagnosis and tumor resistance research.This article also explores the role of eccDNA as a potential diagnostic biomarker and therapeutic target in prostate cancer.

关 键 词：前列腺癌 染色体外环状DNA 染色体外DNA 癌基因扩增 肿瘤进化 

分 类 号：R737.25[医药卫生—肿瘤]