扶正辟邪颗粒挥发油提取及包合工艺研究  

Study on Extraction and Inclusion Processes of Volatile Oil from Fuzheng Pixie Granules

作　　者：罗群 任桂林 蒲清荣 任维 王饶琼 梁盼 杨思进 Luo Qun;Ren Guilin;Pu Qingrong;Ren Wei;Wang Raoqiong;Liang Pan;Yang Sijin(The Affiliated Traditional Chinese Medicine Hospital,Southwest Medical University,Luzhou,Sichuan 646000,China)

机构地区：[1]西南医科大学附属中医医院,四川泸州646000

出　　处：《大理大学学报》2024年第2期4-7,共4页Journal of Dali University

基　　金：四川省中医药管理局项目(2021XYCZ006);西南医科大学-附属中医医院联合项目(2020XYLH-004)。

摘　　要：目的:优化扶正辟邪颗粒挥发油提取及包合工艺。方法:采用L_(9)(3^(4))正交设计试验,以挥发油得油率为指标,优选挥发油提取工艺;以包合物收率和挥发油包合率为指标,优选挥发油β-环糊精包合工艺。结果:最佳挥发油提取工艺为10倍量的水,浸泡0.5 h,提取4.5 h,3次验证试验平均挥发油得油率为(0.91±0.01)%;最佳挥发油包合工艺为β-环糊精与挥发油比例为10:1,包合温度40℃,包合3 h,3次验证试验平均包合物收率为(84.48±0.75)%,平均挥发油包合率为(90.69±0.79)%。结论:扶正辟邪颗粒挥发油最佳提取工艺及最佳包合工艺设计合理、结果稳定,适宜于工业生产。Objective: To optimize the extraction and inclusion process of volatile oil from Fuzheng Pixie granules. Methods: L9(34)orthogonal design experiment was used to optimize the extraction process of volatile oil, with the oil yield as the index. The inclusionprocess of volatile oil with β-cyclodextrin was optimized with the yield of inclusion complex and the inclusion rate of volatile oil as theindexes. Results: The optimal extraction process of volatile oil was soaking in 10 times the amount of water for 0.5 hours, followed byextraction for 4.5 hours. The average oil yield of volatile oil in three verification tests was (0.91±0.01)%. The optimal inclusion processof volatile oil was a ratio of β-cyclodextrin to volatile oil of 10:1, inclusion temperature of 40 ℃, and inclusion time of 3 hours. Theaverage yield of inclusion complex in three verification tests was (84.48±0.75)%, and the average inclusion rate of volatile oil was(90.69±0.79)% . Conclusion: The optimal extraction process and the optimal inclusion process of volatile oil of Fuzheng Pixiegranules are reasonable in design and stable in results, which are suitable for industrial production.

关 键 词：扶正辟邪颗粒 挥发油 Β-环糊精 提取工艺 包合工艺 

分 类 号：R283.6[医药卫生—中药学]