明胶海绵-凝血酶原-碘海醇用于封堵CT引导下经皮肝穿刺活检针道  

Gelatin sponge-prothrombin-iohexol for blocking needle path of CT-guided percutaneous liver biopsy

作　　者：熊峻汶 廖发超 翟越 王炎 陈志明 XIONG Junwen;LIAO Fachao;ZHAI Yue;WANG Yan;CHEN Zhiming(Department of Radiology,the Affiliated Hospital of Kunming University of Science and Technology,the First People’s Hospital of Yunnan Province,Kunming 650032,China)

机构地区：[1]昆明理工大学附属医院云南省第一人民医院放射科,云南昆明650032

出　　处：《中国介入影像与治疗学》2024年第2期75-78,共4页Chinese Journal of Interventional Imaging and Therapy

摘　　要：目的 观察明胶海绵-凝血酶原-碘海醇用于封堵CT引导下经皮肝穿刺活检针道的安全性及可行性。方法回顾性分析101例因不明原因肝病、肝硬化、肝占位性病变并发凝血功能异常而接受CT引导下肝穿刺活检患者,穿刺取材后均以明胶海绵颗粒-人凝血酶原复合物-碘海醇混合物封堵针道;观察穿刺活检效果、并发症及穿刺前后凝血及肝功能指标。结果 101例均穿刺取材成功,技术成功率及组织学标本充分度均为100%,并均获得明确病理诊断。18例(18/101,17.82%)出现并发症,包括穿刺部位轻微疼痛、封堵剂渗透至肝包膜下或皮下;未见出血、气胸及胆管损伤等严重并发症。穿刺活检前、后凝血及肝功能差异均无统计学意义(P均>0.05)。结论 明胶海绵颗粒-凝血酶原-碘海醇用于封堵经皮肝穿刺活检针道安全、可靠,可减少出血等并发症。Objective To observe the safety and feasibility of gelatin sponge-prothrombin-iohexol for blocking needle path of CT-guided percutaneous liver biopsy.Methods Totally 101 patients who underwent CT-guided needle biopsy of liver due to unexplained liver diseases,cirrhosis or space-occupying lesions of liver with coagulation dysfunction were retrospectively analyzed.After biopsy,the puncture needle path was blocked with gelatin sponge-prothrombin-iohexol.The effect and complications of puncture,also patients’coagulation and liver function indicators before and after puncture were observed.Results Successful puncture and sampling were performed in all 101 cases,with both technical success rate and adequacy of histological specimens of 100%.Accurate pathological diagnose was acquired in all 101 cases.Complications including mild pain at the puncture site,penetration of the blocking agent into the liver capsule or subcutaneous tissue were observed in a total of 18 cases(18/101,17.82%),while no severe complication such as bleeding,pneumothorax or bile duct injury occurred.No significant difference of coagulation nor liver function indicators was found before and after CT-guided needle biopsy(all P>0.05).Conclusion Gelatin sponge-prothrombin-iohexol were safe and reliable for blocking needle path of percutaneous liver biopsy,which could reduce complications such as bleeding.

关 键 词：肝疾病 肝肿瘤 穿刺术 活组织检查 体层摄影术 X线计算机 

分 类 号：R575[医药卫生—消化系统] R814.42[医药卫生—内科学]