基于钆塞酸二钠增强肝胆期MRI构建影像组学模型评估肝纤维化临床病理分期  

Radiomics models based on gadolinium-ethoxybenzyl-diethylenetriamine pentaacetic acid enhanced hepatobiliary phase MRI for assessing clinical pathological stage of hepatic fibrosis

作　　者：任毓凡 胡根文 钟淑媛 吕嘉淇 卢浩钧 邹锦森 李欣明[1] 全显跃[1] REN Yufan;HU Genwen;ZHONG Shuyuan;LYU Jiaqi;LU Haojun;ZOU Jinsen;LI Xinming;QUAN Xianyue(Department of Radiology,Zhujiang Hospital of Southern Medical University,Guangzhou 510200,China;Department of Radiology,Shenzhen People’s Hospital,Shenzhen 518000,China)

机构地区：[1]南方医科大学珠江医院影像诊断科,广东广州510200 [2]深圳市人民医院(暨南大学第二临床医学院)放射科,广东深圳518000

出　　处：《中国介入影像与治疗学》2024年第2期94-99,共6页Chinese Journal of Interventional Imaging and Therapy

基　　金：国家自然科学基金(82171893、82370674)。

摘　　要：目的 观察基于钆塞酸二钠(Gd-EOB-DTPA)增强肝胆期(HBP)MRI构建的影像组学模型评估肝纤维化(HF)临床病理分期的价值。方法 回顾性分析接受Gd-EOB-DTPA增强MR检查并经病理/临床评估HF临床病理分期的240例患者资料,测量HBP肝脏-肌肉信号强度比值(SIR1)及肝脏-脾脏信号强度比值(SIR2);提取并筛选HBP影像组学特征,构建影像组学模型;基于信号强度比值(SIR)及影像组学标签构建SIR-影像组学联合模型;以受试者工作特征(ROC)曲线分析各模型评估HF临床病理分期的效能。结果 SIR1与SIR2评估HF临床病理分期的曲线下面积(AUC)分别为0.63~0.70及0.65~0.71。评估HF、显著HF、进展期HF及早期肝硬化效能最高的影像组学模型分别为支持向量机(SVM)、SVM、轻量梯度提升机及K邻近法模型(验证集AUC分别为0.87、0.82、0.81及0.80)。SIR-影像组学联合模型评估验证集上述HF临床病理分期的AUC分别为0.88、0.82、0.82及0.81。结论 基于GdEOB-DTPA增强HBP MRI构建的影像组学模型有助于评估HF临床病理分期;联合HBP SIR可提高评估其效能。Objective To observe the value of radiomics models based on gadolinium ethoxybenzyl diethylenetriamine pentaacetic acid(Gd-EOB-DTPA)enhanced hepatobiliary phase(HBP)MRI for assessing clinical pathological stage of hepatic fibrosis(HF).Methods Data of 240 patients with pathologically/clinically diagnosed and clinical pathological staged HF who underwent Gd-EOB-DTPA enhanced MR examination were retrospectively analyzed.The liver-to-muscle signal intensity ratio(SIR1)and liver-to-spleen signal intensity ratio(SIR2)were measured based on HBP images.Radiomics features of HBP images were extracted and screened to construct radiomics models.The signal intensity ratio(SIR)-radiomics combined models were constructed based on SIR and radiomics signatures.Receiver operating characteristic(ROC)curves were drawn to evaluate the efficacy of each model for assessing clinical pathological stage of HF.Results The area under the curve(AUC)of SIR1 and SIR2 models for assessing clinical pathological stage of HF were 0.63—0.70 and 0.65—0.71,respectively.The most effective radiomics model for assessing HF,significant HF,advanced HF and early cirrhosis was support vector machine(SVM),SVM,light gradient boosting machine and K-nearest neighbor model,respectively,with the AUC in validation set of 0.87,0.82,0.81 and 0.80,respectively,while the AUC of SIR-radiomics combined models in validation set of 0.88,0.82,0.82 and 0.81,respectively.Conclusion The radiomics models based on Gd-EOB-DTPA enhanced HBP MRI were helpful for assessing clinical pathological stage of HF.Combining with HBP SIR could improve their efficacy.

关 键 词：肝硬化 对比剂 磁共振成像 影像组学 

分 类 号：R575.29[医药卫生—消化系统] R445.2[医药卫生—内科学]