迷走神经胆碱能抗炎通路与偏头痛的关系探讨  

Exploration of the relationship between vagal cholinergic anti-inflammatory pathway and migraine

作　　者：李凤鹏 邢红霞 靳玫[1] 殷闯[1] 周立[2] LI Feng-peng;XING Hong-xia;JIN Mei;YIN Chuang;ZHOU Li(Department of Neurology,The Third Affiliated Hospital of Xinxiang Medical University,Xinxiang 453003,China;Department of Human Anatomy and Histoembryology,Xinxiang Medical University,Xinxiang 453003,China)

机构地区：[1]新乡医学院第三附属医院神经内科,新乡453003 [2]新乡医学院人体解剖学与组织胚胎学系,新乡453003

出　　处：《中国疼痛医学杂志》2024年第2期114-118,124,共6页Chinese Journal of Pain Medicine

基　　金：河南省科技攻关项目(202102310348);新乡医学院第三附属医院博士启动基金(BSKYJF)。

摘　　要：偏头痛是一种发病率高、致残率高的原发性头痛,发病机制尚未完全明确。近期研究表明,微生物群-肠-脑轴理论可能参与其发病。胆碱能抗炎通路(cholinergicanti-inflammatorypathway,CAP),是微生物群-肠-脑轴理论的一个重要研究领域。CAP与偏头痛发作的头痛症状和消化道症状均有关联。本文就CAP与偏头痛关系的研究进展进行综述,以期为偏头痛发病机制的研究提供新思路。Migraine is a kind of primary headache with high incidence rate and high disability rate.The patho-genesis has not yet been completely elucidated.Recent studies have shown that the microbiota-gut-brain axis may be involved in its pathogenesis.Cholinergic anti-inflammatory pathway(CAP)is an important researchfield in the microbiota-gut-brain axis.CAP is associated with both headache symptoms and gastrointestinal symptoms of migraine attacks.There have been reports on the correlation between CAP and migraine,as well as the correlation between CAP and gastrointestinal comorbidities with migraine.This review discusses the research progress on the relationship between CAP and migraine,in order to provide new ideas for the study of the pathogenesis of migraine.

关 键 词：偏头痛 胆碱能抗炎通路 迷走神经刺激 Α7烟碱型乙酰胆碱受体 

分 类 号：R747.2[医药卫生—神经病学与精神病学]