朱砂根抗肿瘤作用研究进展  

Antitumor mechanism of Ardisia Crenata Radix

作　　者：任群利 罗倩 刘华倩 吴发明 何芋岐 刘建国 王倩 REN Qunli;LUO Qian;LIU Huaqian;WU Faming;HE Yuqi;LIU Jianguo;WANG Qian(Microbial Resources and Drug Development Key Laboratory of Guizhou Tertiary Institution,School of Stomatology,Zunyi Medical University,Zunyi 563000;China.2.School of Basic Medical,Zunyi Medical University,Zunyi 563000;.3.School of Pharmacy,Zunyi Medical University,Zunyi 563000)

机构地区：[1]遵义医科大学口腔医学院,贵州省普通高等学校微生物资源及药物开发特色重点实验室,贵州遵义563000 [2]遵义医科大学基础医学院,贵州遵义563000 [3]遵义医科大学药学院,贵州遵义563000

出　　处：《中国比较医学杂志》2024年第1期165-170,共6页Chinese Journal of Comparative Medicine

基　　金：贵州省教育厅乡村振兴继承示范村建设项目(黔教技[2022]037号);遵义市科技局计划项目(遵市科合HZ字(2020)60号,遵市科合HZ字(2020)55号);贵州省科技计划项目(黔科合平台人才[2018]5772-067,黔科合平台人才[2018]5772-062)。

摘　　要：朱砂根是中国传统中药,属于紫金牛科植物,其主要成分为香豆素类、皂苷类、黄酮类和挥发油等。随着对朱砂根抗肿瘤作用的深入研究,其活性抗癌化合物有岩白菜素、朱砂根皂苷A、B、百两金皂苷A、B和蒽贝素,主要通过诱导肿瘤细胞凋亡、增加肿瘤细胞毒性抑制细胞增殖、抑制肿瘤细胞转移和迁徙等多种途径在口腔癌、鼻咽癌、肝癌、结肠癌、膀胱癌、宫颈癌和白血病等肿瘤中显示出很高的抗肿瘤潜力。然而,朱砂根的抗肿瘤机制临床前实验数据缺乏高质量、多样本、多重复的随机对照试验,临床研究数据缺乏肿瘤预后及药效学和药代动力学相关试验数据,应设计精准研究实验和临床试验进一步探索挖掘朱砂根的药理作用。Ardisia Crenata Radix is a traditional Chinese medicinal plant that belongs to the Myrsinaceae family,and its main active components are coumarins,saponins,flavonoids,and volatile oil.Bergenin,ardisicrenoside A,ardisicrenoside B,ardisiacripin A,ardisiacripin B,and embelin were identified as active anticancer compounds in in-depth studies into the anti-tumor effects of Ardisia Crenata Radix.They show high therapeutic potential in oral cancer,nasopharyngeal carcinoma,liver cancer,colon cancer,bladder cancer,cervical cancer,and leukemia,mainly by inducing tumor cell apoptosis,increasing tumor cytotoxicity,inhibiting cell proliferation,inhibiting tumor cell metastasis and migration,and inducing cell regulatory enzyme cascade reactions.However,most preclinical experimental data on cinnabar root’s anti-tumor mechanism have not been verified in high-quality,multi-sample,and repeated randomized controlled trials,and there are a lack of clinical research data on tumor prognosis,pharmacodynamics,and pharmacokinetics.Accurate research experiments and clinical trials should be designed to further explore the pharmacological effects of Ardisia Crenata Radix.

关 键 词：朱砂根 岩白菜素 肿瘤 抗癌化合物 

分 类 号：R-33[医药卫生]