SHP-2在肿瘤相关巨噬细胞中的研究进展  

Research progress on the role of SHP-2 in tumor-associated macrophages

作　　者：武雪亮[1,2] 樊建春 郭飞[1] 张琦[4] 薛军[1,2] 王西墨[4] 孙光源 刘建玲 韩磊[1] 高树全[1] WU Xueliang;FAN Jianchun;GUO Fei;ZHANG Qi;XUE Jun;WANG Ximo;SUN Guangyuan;LIU Jianling;HAN Lei;GAO Shuquan(Department of General Surgery,the First Hospital Affiliated to Hebei North University,Zhangjiakou 075000;China.2.Cancer Research Institue,the First Hospital Affiliated to Hebei North University,Zhangjiakou 075000;.3.Hebei North University,Zhangjiakou 075000;.4.Nankai Clinical College Affiliated to Tianjin Medical University,Tianjin 300100)

机构地区：[1]河北北方学院附属第一医院普通外科,河北张家口075000 [2]河北北方学院附属第一医院肿瘤研究所,河北张家口075000 [3]河北北方学院,河北张家口075000 [4]天津医科大学附属南开临床学院,天津300100

出　　处：《中国比较医学杂志》2024年第1期171-176,共6页Chinese Journal of Comparative Medicine

基　　金：2022年河北省省自然科学精准医学联合基金项目(H2022405033)。

摘　　要：肿瘤相关巨噬细胞(TAMs)是肿瘤免疫微环境(TIME)中的优势细胞群,是TIME中免疫系统抑制和肿瘤细胞增殖最重要的调节细胞。Src同源2蛋白酪氨酸磷酸酶2(SHP-2)是一种非受体蛋白酪氨酸磷酸酶,该磷酸酶在从细胞表面到细胞核的信号传递中发挥重要作用,且是介导细胞增殖和分化的关键细胞内调节因子,参与多种生长因子和细胞因子的信号通路。最近的研究表明,SHP-2是决定TAMs功能的一个关键酶,但是由于其功能多变,在不同的实体瘤微环境中发挥不同甚至是相反的作用。基于此,本文综述了SHP-2在TAMs功能及在相关实体瘤中的作用,为肿瘤的免疫和靶向治疗提供坚实的科学依据。Tumor-associated macrophages(TAMs)are the predominant cell group in the tumor microenvironment(TME)and are the most important regulatory cells of immune system suppression and tumor cell proliferation in TIME.Src homology-2 domain-containing protein tyrosine phosphatase 2(SHP-2)is a non-receptor protein tyrosine phosphatase that plays an important role in the transmission of signals from the cell surface to the nucleus.SHP-2 is a key intracellular regulatory factor mediating cell proliferation and differentiation and is involved in a variety of growth factor and cytokine signaling pathways linking the cell surface to the nucleus.Recent studies have shown that SHP-2 is a key enzyme in determining the function of TAMs,but because of its variable function,it plays different or even opposite roles in different solid TMEs.This paper reviews the function of SHP-2 in TAMs and related solid tumors to provide a comprehensive reference for tumor immunity and targeted therapy research.

关 键 词：蛋白酪氨酸磷酸酶2 肿瘤相关巨噬细胞 临床研究 作用机制 

分 类 号：R-33[医药卫生]