双氢青蒿素抗消化道恶性肿瘤作用及机制研究进展  

Research progress of dihydroartemisinin against gastrointestinal malignant tumors and its mechanism of action

作　　者：骆李康 王译峰 陈云洋 李春艳 杨晓军 LUO Likang;WANG Yifeng;CHEN Yunyang;LI Chunyan;YANG Xiaojun(The First Clinical Medical College of Gansu University of Chinese Medicine,Gansu Lanzhou 730000,China;The First Clinical College of Medicine,Lanzhou University,Gansu Lanzhou 730000,China;Department of Hepatobiliary Medicine,Gansu Provincial People's Hospital,Gansu Lanzhou 730000,China;Key Laboratory of Molecular Diagnosis and Precision Therapy of Surgical Tumors in Gansu Province,Gansu Lanzhou 730000,China;Gansu Provincial Engineering Research Center for Prevention and Control of Gastrointestinal Malignancies,Gansu Lanzhou 730000,China)

机构地区：[1]甘肃中医药大学第一临床医学院,甘肃兰州730000 [2]兰州大学第一临床医学院,甘肃兰州730000 [3]甘肃省人民医院肝胆科,甘肃兰州730000 [4]甘肃省外科肿瘤分子诊断与精准治疗重点实验室,甘肃兰州730000 [5]甘肃省消化道恶性肿瘤防控工程研究中心,甘肃兰州730000

出　　处：《现代肿瘤医学》2024年第4期737-743,共7页Journal of Modern Oncology

基　　金：国家卫健委胃肠肿瘤诊治重点实验室2022年度硕博士/博士后基金项目(编号:NHCDP2022001);甘肃省省级科技计划重点研发项目(编号:21YF5WA027);甘肃省创新基地和人才项目资助(编号:20JR10RA433);甘肃省卫生健康行业科研计划(编号:GSWSKY2020-45);甘肃省人民医院博士研究生导师培育项目(编号:22GSSYA-3)。

摘　　要：中国是消化道肿瘤较为流行的国家,尽管近十年来在肿瘤筛查、诊断和治疗方面取得了很大进步,但化疗仍然是治疗晚期癌症的主要方法,多重耐药性以及严重不良反应导致大多数晚期患者预后不良。天然分子产物协同抗癌药物增强抗肿瘤效果是一种临床上有前途的策略。双氢青蒿素(dihydroartemisinin,DHA)作为青蒿素的主要活性代谢产物,具有较强的抗疟活性和抗肿瘤作用,其抗肿瘤机制主要是通过加速Fe^(2+)介导的细胞氧化损伤、诱导肿瘤细胞凋亡、停滞细胞周期、抑制肿瘤血管生成、逆转肿瘤细胞的多耐药性等发挥作用。本文主要对DHA的抗消化道肿瘤作用以及分子机制做一综述。China has a higher prevalence of gastrointestinal tumors.Although there have been significant advancements in tumor screening,diagnosis,and treatment in the past decade,chemotherapy remains the primary treatment for advanced cancers.However,multiple drug resistance and severe adverse effects often result in a poor prognosis for most advanced patients.A promising clinical strategy involves combining natural molecular products with anticancer drugs to enhance their anti-tumor effects.Dihydroartemisinin(DHA),the main active metabolite of artemisinin,exhibits potent antimalarial activity and antitumor effects.Its antitumor mechanism primarily involves accelerating Fe^(2+)-mediated oxidative cell damage,inducing apoptosis in tumor cells,arresting the cell cycle,inhibiting tumor angiogenesis,and reversing multidrug resistance in tumor cells.This paper focuses on reviewing the anti-tumor effects of DHA in the digestive tract and exploring the underlying molecular mechanisms.

关 键 词：双氢青蒿素 消化道肿瘤 抗肿瘤作用 综述 

分 类 号：R730.5[医药卫生—肿瘤]