肿瘤相关基因改变与三级淋巴结构形成的关系及对肿瘤预后影响的研究进展  

Research progress on the relationship between tumor-associated gene alterations and tertiary lymphoid structures formation and its effect on tumor prognosis

作　　者：车雨柔 杨曼 李柯臻 董娟 李思敏 张艺耀 徐祝 王梅 罗丽萍 方曾怡 吴川 王卫东 CHE Yurou;YANG Man;LI Kezhen;DONG Juan;LI Simin;ZHANG Yiyao;XU Zhu;WANG Mei;LUO Liping;FANG Zengyi;WU Chuan;WANG Weidong(School of Medicine,University of Electronic Science and Technology of China,Sichuan Chengdu 610054,China;Department of Radiation Oncology,School of Medicine,University of Electronic Science and Technology of China,Sichuan Cancer Center,Sichuan Cancer Hospital and Institute,Sichuan Chengdu 610041,China;School of Clinical Medicine,Southwest Medical University,Sichuan Luzhou 646000,China;Meishan Cancer Hospital,Sichuan Meishan 620020,China;Radiation Oncology,Key Laboratory of Sichuan Province,Sichuan Cancer Center,Sichuan Cancer Hospital and Institute,Sichuan Chengdu 610041,China)

机构地区：[1]电子科技大学医学院,四川成都610054 [2]四川省肿瘤医院·研究所四川省癌症防治中心,电子科技大学医学院放射治疗中心,四川成都610041 [3]西南医科大学临床医学院,四川泸州646000 [4]眉山肿瘤医院,四川眉山620020 [5]四川省肿瘤医院·研究所四川省癌症防治中心,放射肿瘤学四川省重点实验室,四川成都610041

出　　处：《现代肿瘤医学》2024年第4期758-766,共9页Journal of Modern Oncology

基　　金：四川省自然科学基金重点项目(编号:2022NSFSC0051);四川省肿瘤医院临床科学家项目(编号:YB2022003);四川省成都市技术创新研发项目(编号:2021YF0501659SN)。

摘　　要：近年来多项研究表明三级淋巴结构(tertiary lymphoid structures,TLS)与大多恶性肿瘤良好预后及免疫治疗疗效相关,对临床的治疗决策选择具有重要作用,但肿瘤相关基因改变和TLS之间的关系还很少被研究,基因改变在TLS诱导调控中的具体作用如何?本文将对肿瘤TLS的组成和结构、形成机制、肿瘤相关基因改变与TLS关系、对肿瘤预后影响、以及未来展望等方面进行综述,更详细地了解TLS的功能及其基因改变在其中的潜在作用,以期为临床精准治疗及新药物的开发提供相关依据。In recent years,several studies have shown that tertiary lymphoid structures(TLS)are associated with good prognosis and immunotherapy efficacy in most malignant tumors and play an important role in clinical treatment options.But the relationship between tumor-associated gene alterations and TLS has rarely been investigated.What is the specific role of gene alterations in the regulation of TLS induction?In this paper,we will review the composition,structure and formation mechanism of TLS,relationship between tumor-associated gene alterations and TLS,impact on tumor prognosis,as well as future perspectives to understand the function of TLS and the potential role of gene alterations in it in more detail,to provide a relevant basis for clinical precision therapy and the development of new drugs.

关 键 词：三级淋巴结构 恶性肿瘤 基因 肿瘤微环境 

分 类 号：R730.231[医药卫生—肿瘤]