过氧化物酶体增殖物激活受体-γ通过调节炎症治疗肿瘤的研究进展  

Advances in peroxisome proliferator-activated receptor-γfor the treatment of cancer through modulation of inflammation

作　　者：赵雅波 王元勇 闫小龙 ZHAO Yabo;WANG Yuanyong;YAN Xiaolong(Thoracic Surgery Laboratory,Second Affiliated Hospital of Air Force Medical University,Shaanxi Xi'an 710038,China;Department of Thoracic Surgery,Second Affiliated Hospital of Air Force Medical University,Shaanxi Xi'an 710038,China)

机构地区：[1]空军军医大学第二附属医院胸腔外科实验室,陕西西安710038 [2]空军军医大学第二附属医院胸腔外科,陕西西安710038

出　　处：《现代肿瘤医学》2024年第4期777-782,共6页Journal of Modern Oncology

基　　金：国家自然科学基金资助项目(编号:82173252)。

摘　　要：过氧化物酶体增殖物激活受体(PPARs)是一组核受体和配体激活的细胞内转录因子,在细胞代谢、增殖、分化、组织重塑、炎症和动脉粥样硬化等生理过程中发挥着关键作用。PPARs还充当着肿瘤抑制因子的角色。PPAR-γ是PPAR家族中最著名的一种,可在结肠癌、乳腺癌、膀胱癌、肺癌和前列腺癌中高表达。PPAR-γ的配体通过PPAR-γ依赖性和独立途径发挥作用,还能调节全身炎症和肿瘤微环境中的不同炎症介质和转录因子。通过激活PPAR-γ的合成配体和天然配体都能通过调节炎症途径抑制肿瘤细胞的生长和繁殖。恶性肿瘤和炎症是相互关联的过程,可通过降低癌细胞带来的风险和负担来抑制肿瘤。因此,PPAR-γ可以作为一个有前途的靶点,用于开发抑制癌细胞增殖的临床药物分子。本文旨在综述强调PPAR-γ作为药物开发的潜在靶点,旨在抗炎从而抑制肿瘤的研究进展。Peroxisome proliferator-activated receptors(PPARs)are a group of nuclear receptor-and ligand-activated intracellular transcription factors that play key roles in physiological processes such as cellular metabolism,proliferation,differentiation,tissue remodelling,inflammation,and atherosclerosis.PPARs also act as tumor suppressors.PPAR-γ,the best-known member of the PPAR family,can be found in colon cancer,breast cancer,bladder cancer,lung cancer and prostate cancer.Ligands for PPAR-γ act through PPAR-γ-dependent and independent pathways and also regulate different inflammatory mediators and transcription factors in the systemic inflammation and tumor microenvironment.By activating both synthetic and natural ligands of PPAR-γ can inhibit the growth and multiplication of tumor cells by regulating inflammatory pathways.Malignant tumors and inflammation are interrelated processes that can suppress tumors by reducing the risk and burden posed by cancer cells.Therefore,PPAR-γ could be a promising target for the development of clinical drug molecules that inhibit cancer cell proliferation.The aim of this paper is to review research advances highlighting PPAR-γ as a potential target for drug development aimed at anti-inflammatory and thus tumor suppression.

关 键 词：过氧化物酶体增殖激活受体-γ 转录因子 肿瘤微环境 炎症 肿瘤发生 抗炎 

分 类 号：R730.5[医药卫生—肿瘤]