术前白蛋白与球蛋白比值与膀胱癌患者预后及临床病理特征相关性的Meta分析  

Correlation of preoperative albumin-globulin ratio with clinicopathological characteristics and prognosis of bladder cancer patients:a Meta-analysis

作　　者：李浩[1] 宋祥伟[1] 张鹏 张鹤骞 滕立臣 Li Hao;Song Xiangwei;Zhang Peng;Zhang Heqian;Teng Lichen(Department of Urology,the First Hospital of Qiqihar,Qiqihar 161000,China;Department of Urology,Harbin Medical University Cancer Hospital,Harbin 150081,China)

机构地区：[1]齐齐哈尔市第一医院泌尿外科,齐齐哈尔161000 [2]哈尔滨医科大学附属肿瘤医院泌尿外科,哈尔滨150081

出　　处：《国际泌尿系统杂志》2024年第1期11-16,共6页International Journal of Urology and Nephrology

摘　　要：目的评价术前白蛋白与球蛋白比值(AGR)与膀胱癌(BC)患者预后及临床病理特征的相关性。方法在PubMed、Cochrane Library、Embase、Web of Science、中国知网、维普数据库和万方数据库中全面检索关于术前AGR与BC预后相关性的研究, 检索时限从建库至2022年7月20日。采用纽卡斯尔-渥太华量表(NOS)对纳入文献进行质量评价, 研究AGR与BC患者预后及临床病理特征的关系。结果本次研究共纳入8篇文献, 包括1 716例BC患者, Meta分析结果显示:术前低水平AGR与较差的总生存期(OS)(HR=2.97, 95%CI:1.38~6.40, P=0.005)、无复发生存期(RFS)(HR=3.33, 95%CI:2.14~5.17, P<0.001)、癌症特异性生存期(CSS)(HR=3.82, 95%CI:2.07~7.07, P<0.001)和无进展生存期(PFS)(HR=3.72, 95%CI:2.33~5.93, P<0.001)均存在相关性。此外, 术前低AGR组与高AGR组的年龄(OR=2.073, 95%CI:1.454~2.955, P<0.001)、肿瘤长径(OR=1.691, 95%CI:1.343~2.129, P<0.001)、淋巴结转移(OR=3.060, 95%CI:1.912~4.899, P<0.001)和MIBC分期(OR=1.957, 95%CI:1.018~3.763, P=0.044)方面比较, 差异均有统计学意义。结论术前低水平AGR与BC患者较差的生存结局和不良的病理特征相关, AGR值有望成为BC的预后判断指标。Objective To evaluate the correlation of preoperative albuminglobulin ratio(AGR)with clinicopathological characteristics and prognosis of bladder cancer(BC)patients.Methods A comprehensive search was conducted in PubMed,Cochrane Library,Embase,Web of Science,CNKI,VIP database and Wanfang database for studies on the correlation between preoperative AGR and BC prognosis from the establishment of the database to July 20,2022.NOS scale was used to evaluate the quality of the included literatures,and the relationship between AGR and the prognosis and clinicopathological features of BC patients was studied.Results A total of 8 articles were included in this study,including 1716 patients with bladder cancer.The results showed that the preoperative AGR was significantly correlated with OS(HR=2.97,95%CI:1.38~6.40,P=0.005)、recurrence-free survival(RFS)(HR=3.33,95%CI:2.14~5.17,P<0.001)、CSS(HR=3.82,95%CI:2.07~7.07,P<0.001)and PFS(HR=3.72,95%CI:2.33~5.93,P<0.001).In addition,the differences between preoperative low AGR group and high AGR group in terms of age(OR=2.073,95%CI:1.454~2.955,P<0.001),tumor diameter(OR=1.691,95%CI:1.343~2.129,P<0.001),lymph node metastases(OR=3.060,95%CI:1.912~4.899,P<0.001)and musc-inrasive bladder cancer(MIBC)stage(OR=1.957,95%CI:1.018~3.763,P=0.044)were statistically significant.Conclusions Preoperative low level of AGR is significantly associated with poor survival outcome and poor pathological features in BC patients and AGR is expected to become a prognostic indicator of BC.

关 键 词：膀胱肿瘤 白蛋白 白球比 

分 类 号：R737.14[医药卫生—肿瘤]