脑性瘫痪共病癫痫的遗传因素、危险因素及发病机制  

Genetic factors,risk factors and pathogenesis of cerebral palsy comorbid epilepsy

作　　者：公超 连贝贝 李雪梅[1,2] 张朋[1,3] 宋凡旭[1,2] 郭津[1,3] GONG Chao;LIAN Beibei;LI Xuemei;ZHANG Peng;SONG Fanxu;GUO Jin(Rehabilitation Medical College of Jiamusi University,Jiamusi,Heilongjiang 154007,China;Department of Pediatric Cerebral Palsy,The Third Affiliated Hospital of Jiamusi University,Jiamusi,Heilongjiang 154007,China;Department of Pediatric Neurology,The Third Affiliated Hospital of Jiamusi University,Jiamusi,Heilongjiang 154007,China)

机构地区：[1]佳木斯大学康复医学院,黑龙江佳木斯154007 [2]佳木斯大学第三附属医院小儿脑瘫科,黑龙江佳木斯154007 [3]佳木斯大学第三附属医院小儿神经科,黑龙江佳木斯154007

出　　处：《中国儿童保健杂志》2024年第2期174-180,共7页Chinese Journal of Child Health Care

基　　金：黑龙江省自然科学基金项目(LH2020H006);黑龙江省教育厅基本科研业务费基础研究项目(2022-KYYWF-0653);黑龙江省教育厅基本科研业务费基础研究项目(2019-KYYWF-1366)。

摘　　要：相较于一般人群,癫痫在脑性瘫痪(CP)人群中患病率很高,是CP严重程度的标志,也是影响CP儿童早期生存率和未来生活质量的重要因素,因此对于CP和癫痫的病因研究尤为重要。本研究将从遗传因素、危险因素以及病理生理机制方面总结CP和癫痫的共患病因,以期为今后研究提供参考。Compared to the general population,there is a higher prevalence of epilepsy in individuals with cerebral palsy(CP).Epilepsy serves as an indicator of CP severity and has a significant impact on the early survival and future quality of life of children with CP.Therefore,it is crucial to investigate the shared mechanisms underlying CP and epilepsy.This study aims to summarize the comorbidity of CP and epilepsy from genetic factors,risk factors,and pathophysiological mechanisms,in order to provide a reference for further research.

关 键 词：脑性瘫痪 癫痫 遗传因素 发病机制 

分 类 号：R742.1[医药卫生—神经病学与精神病学] R742.3[医药卫生—临床医学]