TREM2对小胶质细胞的免疫调控在缺血性卒中中的作用  

Role of TREM2-mediated immunomodulation of microglia in ischemic stroke

作　　者：刘斯捷 张文浩[1,2] 汤诗怡 詹丽璇 Liu Sijie;Zhang Wenhao;Tang Shiyi;Zhan Lixuan(Department of Neurology,the Second Affiliated Hospital of Guangzhou Medical University,Institute of Neuroscience,Guangzhou Medical University Guangzhou 510260,China;Key Laboratory for Regenerative Medicine of Ministry of Education,Jinan University,Guangzhou 510632,China)

机构地区：[1]广州医科大学附属第二医院神经内科,广州医科大学神经科学研究所,广州510260 [2]暨南大学再生医学教育部重点实验室,广州510632

出　　处：《国际脑血管病杂志》2023年第10期773-778,共6页International Journal of Cerebrovascular Diseases

基　　金：国家自然科学基金面上项目(82271330);广东省自然科学基金面上项目(2023A1515010210);广东省教育厅特色创新项目(2022KTSCX101);再生医学教育部重点实验室(暨南大学)开放基金(ZSYXM202210)。

摘　　要：缺血性卒中是一种常见的神经系统疾病, 可导致神经元死亡和神经功能障碍。小胶质细胞是中枢神经系统的主要免疫细胞, 参与卒中后炎症和组织修复。髓样细胞表达的触发受体2(triggering receptor expressed on myeloid cells 2, TREM2)是一种在小胶质细胞表面表达的受体, 在缺血性卒中后神经元存活和神经修复方面发挥着多方面的作用, 包括促进小胶质细胞的吞噬作用、抑制过度的炎症反应、维持小胶质细胞的增殖和存活、保护神经元免受损伤以及促进神经功能恢复。因此, 阐明脑缺血后TREM2对小胶质细胞的免疫调节机制, 对于探索缺血性卒中新的治疗方向具有重要意义。Ischemic stroke is a common neurological disorder that can lead to neuronal death and neurological dysfunction.Microglia is the main immune cells in the central nervous system,involved in post-stroke inflammation and tissue repair.Triggering receptor expressed on myeloid cells 2(TREM2),a receptor expressed on the surface of microglia,plays a multifaceted role in neuronal survival and nerve repair after ischemic stroke,including promoting the phagocytosis of microglia,inhibiting excessive inflammatory response,maintaining the proliferation and survival of microglia,protecting neurons from damage,and promoting the recovery of nerve function.Therefore,elucidating the immunoregulatory mechanism of TREM2 on microglia after cerebral ischemia is of great significance for exploring new therapeutic directions for ischemic stroke.

关 键 词：缺血性卒中 受体 免疫 膜糖蛋白类 小胶质细胞 吞噬作用 炎症 神经保护 

分 类 号：R743.3[医药卫生—神经病学与精神病学]