脑动静脉畸形的发病机制  

Pathogenesis of brain arteriovenous malformations

作　　者：李仁 王小刚[1] 李子傲 郭庚[2] Li Ren;Wang Xiaogang;Li Zi’ao;Guo Geng(Department of Neurosurgery,the First Hospital of Shanxi Medical University,Taiyuan 030001,China;Emergency Medical Center,the First Hospital of Shanxi Medical University,Taiyuan 030001,China)

机构地区：[1]山西医科大学第一医院神经外科,太原030001 [2]山西医科大学第一医院急诊医学中心,太原030001

出　　处：《国际脑血管病杂志》2023年第10期779-784,共6页International Journal of Cerebrovascular Diseases

摘　　要：脑动静脉畸形(brain arteriovenous malformations, bAVMs)是一种复杂的先天性脑血管病变, 由于缺乏常见的毛细血管, 导致血液直接从动脉流入静脉, 在动静脉之间形成异常形态的血管畸形团。bAVMs通常因"癫痫、颅内出血、局灶性神经功能障碍"而被发现, 发病率低但致死和致残率高。不过, bAVMs的具体发病机制尚不完全清楚。文章从bAVMs发病相关的信号通路、病理生理学机制、非编码RNAs等方面进行综述, 期望为bAVMs的提供新的诊疗策略。Brain arteriovenous malformations(bAVMs)are a complex congenital cerebrovascular disease.The lack of common capillaries results in blood flowing directly from the arteries to the veins,forming abnormal vascular malformations between the arteries and veins.BAVMs are usually found due to"epilepsy,intracranial hemorrhage,and focal neurological dysfunction",with a low incidence rate but a high mortality and disability rate.However,the specific pathogenesis of bAVMs is not fully understood.This article reviews the signaling pathways,pathophysiological mechanisms,and non-coding RNAs related to the pathogenesis of bAVMs,with the aim of providing new diagnostic and therapeutic strategies for bAVMs.

关 键 词：颅内动静脉畸形 信号转导 新生血管化 病理性 炎症 多态现象 单核苷酸 DNA甲基化 

分 类 号：R743.4[医药卫生—神经病学与精神病学]