外周血红蛋白红细胞分布宽度比值与性别的交互作用对非小细胞肺癌预后的影响  

Effect of the ratio of peripheral hemoglobin to red blood cell distribution width and sex interaction on prognosis of non-small cell lung cancer

作　　者：黄玉夏 李丽[1] 黄晓蔚[1] 梁蔚繁 杨艺[1] 梁清君 HUANG Yuxia;LI Li;HUANG Xiaowei;LIANG Weifan;YANG Yi;LIANG Qingjun(Department of Respiratory and Critical Care Medicine,Baise People′s Hospital,Baise,Guangxi 533000,China)

机构地区：[1]百色市人民医院呼吸与危重症医学科,广西百色533000

出　　处：《临床肺科杂志》2024年第3期381-385,共5页Journal of Clinical Pulmonary Medicine

基　　金：百色市科学研究与技术开发计划(No.百科计20171131)。

摘　　要：目的分析外周血红蛋白/红细胞分布宽度比值(hemoglobin-to-red cell distribution width ratio,HRR)与非小细胞肺癌(non-small cell lung cancer,NSCLC)患者预后的关系,并探究HRR与性别的交互作用对NSCLC患者预后的影响。方法回顾性收集2020年1月至2021年1月在我院就诊的NSCLC患者的临床资料,包括患者人口学资料、疾病特征资料以及实验室检查资料等。根据外周血红蛋白与红细胞分布宽度计算患者的HRR水平,并以中位数为分界线,将患者分为高水平HRR组与低水平HRR组。采用单因素分析探究HRR变化与NSCLC患者不同特征之间的关系。采用Cox相乘交互作用分析HRR与性别的交互作用对NSCLC患者生存情况的影响,并绘制相应的生存曲线。结果NSCLC患者的HRR水平与其性别之间存在交互作用,且此交互作用显著影响患者的预后。在男性患者中,HRR呈低水平者的疾病进展风险是高水平者的3.171倍(95%CI:1.924~6.015,P=0.002)。在女性患者中,不同HRR水平的患者的疾病进展情况无显著差异(P>0.05)。结论HRR与性别的交互作用对NSCLC患者的预后有显著影响。男性NSCLC患者的预后受到HRR影响程度高于女性,在使用HRR作为预后预测因子时应考虑性别差异。Objective To analyze the relationship between the peripheral hemoglobin to red blood cell distribution width(HRR)and the prognosis of patients with non-small cell lung cancer(NSCLC),and to explore the effect of the interaction between HRR and sex on the prognosis of NSCLC patients.Methods The clinical data of NSCLC patients treated in our hospital from January 2020 to January 2021 were retrospectively collected,including patient demographic data,disease characteristics data,and laboratory examination data.The HRR level of patients was calculated according to the distribution width of peripheral hemoglobin and red blood cells.With the median as the dividing line,patients were divided into the high-level HRR group and the low-level HRR group.Single-factor analysis was used to explore the relationship between HRR changes and different characteristics of NSCLC patients.Cox multiplication interaction was used to analyze the impact of the interaction between HRR and gender on the survival of NSCLC patients,and the corresponding survival curve was drawn.Results There is an interaction between the HRR level of NSCLC patients and their gender,and this interaction significantly affects the prognosis of patients.Among male patients,the risk of disease progression of those with low HRR was 3.171 times higher than those with high HRR(95%CI:1.924~6.015,P=0.002).Among female patients,there was no great difference in disease progression between patients with different HRR levels(P>0.05).Conclusion The interaction between HRR and sex has a significant impact on the prognosis of NSCLC patients.The prognosis of male patients with NSCLC is more affected by HRR than that of female patients.Gender differences should be considered when using HRR as a prognostic factor.

关 键 词：非小细胞肺癌 预后 血红蛋白 红细胞分布宽度 交互作用 

分 类 号：R734.2[医药卫生—肿瘤]