从络病理论论治糖尿病骨质疏松症的发病机制  

Exploring the Pathogenesis of Diabetic Osteoporosis from the Perspective of Collateral Disease Theory

作　　者：张亚奇 秦灵灵[2] 白惠中 徐林[1] 左心玮 蒋昇源 赵毅 穆晓红[1] ZHANG Yaqi;QIN Lingling;BAI Huizhong;XU Lin;ZUO Xinwei;JIANG Shengyuan;ZHAO Yi;MU Xiaohong(Dongzhimen Hospital Beijing University of Chinese Medicine,Beijing 100700,China;Beijing University of Chinese Medicine,Beijing 100029,China)

机构地区：[1]北京中医药大学东直门医院,北京100700 [2]北京中医药大学,北京100029

出　　处：《世界中医药》2023年第24期3616-3620,共5页World Chinese Medicine

基　　金：国家自然科学基金项目(81874467)——糖痹康调节AMPK/PGC-1α/SirT3信号通路干预线粒体应激防治糖尿病周围神经病变的机制研究;北京市自然科学基金项目(L192059)——基于多模感知的选择性脊神经后根切断术中腰椎板精准切削及安全性研究。

摘　　要：糖尿病骨质疏松症西医发病机制为高血糖状态下的骨组织生理结构和代谢功能异常,包括长期高血糖、血管损伤及血液循环障碍、脂代谢异常和体内激素水平失调。结合吴以岭教授中医络病学中“气络病变之内分泌功能失调和脉络病变之微循环障碍”理论,可将糖尿病骨质疏松症中医基本病机归纳为脾肾亏虚、脉络瘀阻、骨络失养,最终导致本病的发生和发展。Diabetic osteoporosis in western medicine is characterized by abnormal physiological structure and metabolic function of bone tissue under a hyperglycemic state,including prolonged hyperglycemia,vascular damage and blood circulation dysfunction,lipid metabolism abnormalities and hormonal imbalances.Combined with Professor WU Yiling′s theory of“endocrine dysfunction in Qi-collateral pathology and microcirculation disorders in vascular-collateral pathology”in traditional Chinese medicine(TCM),the basic TCM pathogenesis of diabetic osteoporosis can be summarized as spleen and kidney deficiency,obstruction of collaterals,bone-collaterals malnourishment,eventually leading to the occurrence and development of the disease.

关 键 词：糖尿病骨质疏松症 骨络构效失常 络病理论 脾肾亏虚 脉络瘀阻 发病机制 

分 类 号：R224[医药卫生—中医基础理论] R259[医药卫生—中医学]